Structure of 7-hy­droxy-3-(2-meth­oxy­phen­yl)-2-tri­fluoro­meth­yl-4H-chromen-4-one

Herein, the synthesis and crystal structure of 7-hy­droxy-3-(2-meth­oxy­phen­yl)-2-tri­fluoro­meth­yl-4H-chromen-4-one, C(17)H(11)F(3)O(4), are reported. This isoflavone is used as a starting material in the preparation an array of potent and competitive FPR antagonists. The pyran ring significantly...

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Detalles Bibliográficos
Autores principales: Low, John Nicolson, Gomes, Ligia R., Gaspar, Alexandra, Borges, Fernanda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2017
Materias:
Research Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598833/
https://www.ncbi.nlm.nih.gov/pubmed/28932421
http://dx.doi.org/10.1107/S2056989017009896
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author Low, John Nicolson
Gomes, Ligia R.
Gaspar, Alexandra
Borges, Fernanda
author_facet Low, John Nicolson
Gomes, Ligia R.
Gaspar, Alexandra
Borges, Fernanda
author_sort Low, John Nicolson
collection PubMed
description Herein, the synthesis and crystal structure of 7-hy­droxy-3-(2-meth­oxy­phen­yl)-2-tri­fluoro­meth­yl-4H-chromen-4-one, C(17)H(11)F(3)O(4), are reported. This isoflavone is used as a starting material in the preparation an array of potent and competitive FPR antagonists. The pyran ring significantly deviates from planarity and the dihedral angle between the benzo­pyran mean plane and that of the exocyclic benzene ring is 88.18 (4)°. In the crystal, O—H⋯O hydrogen bonds connect the mol­ecules into C(8) chains propagating in the [010] direction.
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spelling pubmed-55988332017-09-20 Structure of 7-hy­droxy-3-(2-meth­oxy­phen­yl)-2-tri­fluoro­meth­yl-4H-chromen-4-one Low, John Nicolson Gomes, Ligia R. Gaspar, Alexandra Borges, Fernanda Acta Crystallogr E Crystallogr Commun Research Communications Herein, the synthesis and crystal structure of 7-hy­droxy-3-(2-meth­oxy­phen­yl)-2-tri­fluoro­meth­yl-4H-chromen-4-one, C(17)H(11)F(3)O(4), are reported. This isoflavone is used as a starting material in the preparation an array of potent and competitive FPR antagonists. The pyran ring significantly deviates from planarity and the dihedral angle between the benzo­pyran mean plane and that of the exocyclic benzene ring is 88.18 (4)°. In the crystal, O—H⋯O hydrogen bonds connect the mol­ecules into C(8) chains propagating in the [010] direction. International Union of Crystallography 2017-07-07 /pmc/articles/PMC5598833/ /pubmed/28932421 http://dx.doi.org/10.1107/S2056989017009896 Text en © Low et al. 2017 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.http://creativecommons.org/licenses/by/2.0/uk/
spellingShingle Research Communications
Low, John Nicolson
Gomes, Ligia R.
Gaspar, Alexandra
Borges, Fernanda
Structure of 7-hy­droxy-3-(2-meth­oxy­phen­yl)-2-tri­fluoro­meth­yl-4H-chromen-4-one
title Structure of 7-hy­droxy-3-(2-meth­oxy­phen­yl)-2-tri­fluoro­meth­yl-4H-chromen-4-one
title_full Structure of 7-hy­droxy-3-(2-meth­oxy­phen­yl)-2-tri­fluoro­meth­yl-4H-chromen-4-one
title_fullStr Structure of 7-hy­droxy-3-(2-meth­oxy­phen­yl)-2-tri­fluoro­meth­yl-4H-chromen-4-one
title_full_unstemmed Structure of 7-hy­droxy-3-(2-meth­oxy­phen­yl)-2-tri­fluoro­meth­yl-4H-chromen-4-one
title_short Structure of 7-hy­droxy-3-(2-meth­oxy­phen­yl)-2-tri­fluoro­meth­yl-4H-chromen-4-one
title_sort structure of 7-hy­droxy-3-(2-meth­oxy­phen­yl)-2-tri­fluoro­meth­yl-4h-chromen-4-one
topic Research Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598833/
https://www.ncbi.nlm.nih.gov/pubmed/28932421
http://dx.doi.org/10.1107/S2056989017009896
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