Cargando…
A one-year prospective study of colonization with antimicrobial-resistant organisms on admission to a Vietnamese intensive care unit
There is a paucity of data regarding initial bacterial colonization on admission to Intensive Care Units (ICUs) in low and middle-income countries (LMICs). Patients admitted to ICUs in LMICs are at high-risk of subsequent infection with antimicrobial-resistant organisms (AROs). We conducted a prospe...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599024/ https://www.ncbi.nlm.nih.gov/pubmed/28910379 http://dx.doi.org/10.1371/journal.pone.0184847 |
_version_ | 1783264023455727616 |
---|---|
author | Thuy, Duong Bich Campbell, James Hoang, Nguyen Van Minh Trinh, Truong Thi Thuy Duong, Ha Thi Hai Hieu, Nguyen Chi Duy, Nguyen Hoang Anh Hao, Nguyen Van Baker, Stephen Thwaites, Guy E. Chau, Nguyen Van Vinh Thwaites, C. Louise |
author_facet | Thuy, Duong Bich Campbell, James Hoang, Nguyen Van Minh Trinh, Truong Thi Thuy Duong, Ha Thi Hai Hieu, Nguyen Chi Duy, Nguyen Hoang Anh Hao, Nguyen Van Baker, Stephen Thwaites, Guy E. Chau, Nguyen Van Vinh Thwaites, C. Louise |
author_sort | Thuy, Duong Bich |
collection | PubMed |
description | There is a paucity of data regarding initial bacterial colonization on admission to Intensive Care Units (ICUs) in low and middle-income countries (LMICs). Patients admitted to ICUs in LMICs are at high-risk of subsequent infection with antimicrobial-resistant organisms (AROs). We conducted a prospective, observational study at the Hospital for Tropical Diseases in Ho Chi Minh City, Vietnam from November 2014 to January 2016 to assess the colonization and antimicrobial susceptibility of Staphylococcus aureus, Escherichia coli, Klebsiella spp., Pseudomonas spp. and Acinetobacter spp. among adult patients within 48 hours of ICU admission. We found the admission colonization prevalence (with at least one of the identified organisms) was 93.7% (785/838) and that of AROs was 63.1% (529/838). The colonization frequency with AROs among patients admitted from the community was comparable to those transferred from other hospitals (62.2% vs 63.8%). Staphylococcus aureus was the most commonly isolated bacteria from nasal swabs (13.1%, 110/838) and the methicillin-resistant Staphylococcus aureus nasal colonization prevalence was 8.6% (72/838). We isolated Escherichia coli from rectal swabs from almost all enrolled patients (88.3%, 740/838) and 52.1% (437/838) of patients were colonized by extended spectrum β-lactamase producing Escherichia coli. Notably, Klebsiella pneumoniae was the most frequently isolated bacteria from the tracheal swabs (11.8%, 18/153). Vietnamese ICU patients have a high rate of colonization with AROs and are thus at risk of subsequent infections with these organisms if good infection control practices are not in place. |
format | Online Article Text |
id | pubmed-5599024 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-55990242017-09-22 A one-year prospective study of colonization with antimicrobial-resistant organisms on admission to a Vietnamese intensive care unit Thuy, Duong Bich Campbell, James Hoang, Nguyen Van Minh Trinh, Truong Thi Thuy Duong, Ha Thi Hai Hieu, Nguyen Chi Duy, Nguyen Hoang Anh Hao, Nguyen Van Baker, Stephen Thwaites, Guy E. Chau, Nguyen Van Vinh Thwaites, C. Louise PLoS One Research Article There is a paucity of data regarding initial bacterial colonization on admission to Intensive Care Units (ICUs) in low and middle-income countries (LMICs). Patients admitted to ICUs in LMICs are at high-risk of subsequent infection with antimicrobial-resistant organisms (AROs). We conducted a prospective, observational study at the Hospital for Tropical Diseases in Ho Chi Minh City, Vietnam from November 2014 to January 2016 to assess the colonization and antimicrobial susceptibility of Staphylococcus aureus, Escherichia coli, Klebsiella spp., Pseudomonas spp. and Acinetobacter spp. among adult patients within 48 hours of ICU admission. We found the admission colonization prevalence (with at least one of the identified organisms) was 93.7% (785/838) and that of AROs was 63.1% (529/838). The colonization frequency with AROs among patients admitted from the community was comparable to those transferred from other hospitals (62.2% vs 63.8%). Staphylococcus aureus was the most commonly isolated bacteria from nasal swabs (13.1%, 110/838) and the methicillin-resistant Staphylococcus aureus nasal colonization prevalence was 8.6% (72/838). We isolated Escherichia coli from rectal swabs from almost all enrolled patients (88.3%, 740/838) and 52.1% (437/838) of patients were colonized by extended spectrum β-lactamase producing Escherichia coli. Notably, Klebsiella pneumoniae was the most frequently isolated bacteria from the tracheal swabs (11.8%, 18/153). Vietnamese ICU patients have a high rate of colonization with AROs and are thus at risk of subsequent infections with these organisms if good infection control practices are not in place. Public Library of Science 2017-09-14 /pmc/articles/PMC5599024/ /pubmed/28910379 http://dx.doi.org/10.1371/journal.pone.0184847 Text en © 2017 Thuy et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Thuy, Duong Bich Campbell, James Hoang, Nguyen Van Minh Trinh, Truong Thi Thuy Duong, Ha Thi Hai Hieu, Nguyen Chi Duy, Nguyen Hoang Anh Hao, Nguyen Van Baker, Stephen Thwaites, Guy E. Chau, Nguyen Van Vinh Thwaites, C. Louise A one-year prospective study of colonization with antimicrobial-resistant organisms on admission to a Vietnamese intensive care unit |
title | A one-year prospective study of colonization with antimicrobial-resistant organisms on admission to a Vietnamese intensive care unit |
title_full | A one-year prospective study of colonization with antimicrobial-resistant organisms on admission to a Vietnamese intensive care unit |
title_fullStr | A one-year prospective study of colonization with antimicrobial-resistant organisms on admission to a Vietnamese intensive care unit |
title_full_unstemmed | A one-year prospective study of colonization with antimicrobial-resistant organisms on admission to a Vietnamese intensive care unit |
title_short | A one-year prospective study of colonization with antimicrobial-resistant organisms on admission to a Vietnamese intensive care unit |
title_sort | one-year prospective study of colonization with antimicrobial-resistant organisms on admission to a vietnamese intensive care unit |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599024/ https://www.ncbi.nlm.nih.gov/pubmed/28910379 http://dx.doi.org/10.1371/journal.pone.0184847 |
work_keys_str_mv | AT thuyduongbich aoneyearprospectivestudyofcolonizationwithantimicrobialresistantorganismsonadmissiontoavietnameseintensivecareunit AT campbelljames aoneyearprospectivestudyofcolonizationwithantimicrobialresistantorganismsonadmissiontoavietnameseintensivecareunit AT hoangnguyenvanminh aoneyearprospectivestudyofcolonizationwithantimicrobialresistantorganismsonadmissiontoavietnameseintensivecareunit AT trinhtruongthithuy aoneyearprospectivestudyofcolonizationwithantimicrobialresistantorganismsonadmissiontoavietnameseintensivecareunit AT duonghathihai aoneyearprospectivestudyofcolonizationwithantimicrobialresistantorganismsonadmissiontoavietnameseintensivecareunit AT hieunguyenchi aoneyearprospectivestudyofcolonizationwithantimicrobialresistantorganismsonadmissiontoavietnameseintensivecareunit AT duynguyenhoanganh aoneyearprospectivestudyofcolonizationwithantimicrobialresistantorganismsonadmissiontoavietnameseintensivecareunit AT haonguyenvan aoneyearprospectivestudyofcolonizationwithantimicrobialresistantorganismsonadmissiontoavietnameseintensivecareunit AT bakerstephen aoneyearprospectivestudyofcolonizationwithantimicrobialresistantorganismsonadmissiontoavietnameseintensivecareunit AT thwaitesguye aoneyearprospectivestudyofcolonizationwithantimicrobialresistantorganismsonadmissiontoavietnameseintensivecareunit AT chaunguyenvanvinh aoneyearprospectivestudyofcolonizationwithantimicrobialresistantorganismsonadmissiontoavietnameseintensivecareunit AT thwaitesclouise aoneyearprospectivestudyofcolonizationwithantimicrobialresistantorganismsonadmissiontoavietnameseintensivecareunit AT thuyduongbich oneyearprospectivestudyofcolonizationwithantimicrobialresistantorganismsonadmissiontoavietnameseintensivecareunit AT campbelljames oneyearprospectivestudyofcolonizationwithantimicrobialresistantorganismsonadmissiontoavietnameseintensivecareunit AT hoangnguyenvanminh oneyearprospectivestudyofcolonizationwithantimicrobialresistantorganismsonadmissiontoavietnameseintensivecareunit AT trinhtruongthithuy oneyearprospectivestudyofcolonizationwithantimicrobialresistantorganismsonadmissiontoavietnameseintensivecareunit AT duonghathihai oneyearprospectivestudyofcolonizationwithantimicrobialresistantorganismsonadmissiontoavietnameseintensivecareunit AT hieunguyenchi oneyearprospectivestudyofcolonizationwithantimicrobialresistantorganismsonadmissiontoavietnameseintensivecareunit AT duynguyenhoanganh oneyearprospectivestudyofcolonizationwithantimicrobialresistantorganismsonadmissiontoavietnameseintensivecareunit AT haonguyenvan oneyearprospectivestudyofcolonizationwithantimicrobialresistantorganismsonadmissiontoavietnameseintensivecareunit AT bakerstephen oneyearprospectivestudyofcolonizationwithantimicrobialresistantorganismsonadmissiontoavietnameseintensivecareunit AT thwaitesguye oneyearprospectivestudyofcolonizationwithantimicrobialresistantorganismsonadmissiontoavietnameseintensivecareunit AT chaunguyenvanvinh oneyearprospectivestudyofcolonizationwithantimicrobialresistantorganismsonadmissiontoavietnameseintensivecareunit AT thwaitesclouise oneyearprospectivestudyofcolonizationwithantimicrobialresistantorganismsonadmissiontoavietnameseintensivecareunit |