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Refining experimental dental implant testing in the Göttingen Minipig using 3D computed tomography—A morphometric study of the mandibular canal

This study reports morphometric and age-related data of the mandibular canal and the alveolar ridge of the Göttingen Minipig to avoid complications during in vivo testing of endosseus dental implants and to compare these data with the human anatomy. Using 3D computed tomography, six parameters of th...

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Autores principales: Corte, Giuliano M., Plendl, Johanna, Hünigen, Hana, Richardson, Kenneth C., Gemeinhardt, Ole, Niehues, Stefan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599038/
https://www.ncbi.nlm.nih.gov/pubmed/28910382
http://dx.doi.org/10.1371/journal.pone.0184889
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author Corte, Giuliano M.
Plendl, Johanna
Hünigen, Hana
Richardson, Kenneth C.
Gemeinhardt, Ole
Niehues, Stefan M.
author_facet Corte, Giuliano M.
Plendl, Johanna
Hünigen, Hana
Richardson, Kenneth C.
Gemeinhardt, Ole
Niehues, Stefan M.
author_sort Corte, Giuliano M.
collection PubMed
description This study reports morphometric and age-related data of the mandibular canal and the alveolar ridge of the Göttingen Minipig to avoid complications during in vivo testing of endosseus dental implants and to compare these data with the human anatomy. Using 3D computed tomography, six parameters of the mandibular canal as well as the alveolar bone height and the alveolar ridge width were measured in Göttingen Minipigs aged 12, 17 and 21 months. Our null hypothesis assumes that the age and the body mass have an influence on the parameters measured. The study found that the volume, length and depth of the mandibular canal all increase with age. The width of the canal does not change significantly with age. The body mass does not have an influence on any of the measured parameters. The increase in canal volume appears to be due to loss of deep spongy bone in the posterior premolar and molar regions. This reduces the available space for dental implantations, negatively affecting implant stability and potentially the integrity of the inferior alveolar neurovascular bundle. Dynamic anatomical changes occur until 21 months. On ethical grounds, using minipigs younger than 21 months in experimental implant dentistry is inadvisable. Paradoxically the measurements of the 12 months old pigs indicate a closer alignment of their mandibular anatomy to that of humans suggesting that they may be better models for implant studies. Given the variability in mandibular canal dimensions in similar age cohorts, the use of imaging techniques is essential for the selection of individual minipigs for dental prosthetic interventions and thus higher success rates.
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spelling pubmed-55990382017-09-22 Refining experimental dental implant testing in the Göttingen Minipig using 3D computed tomography—A morphometric study of the mandibular canal Corte, Giuliano M. Plendl, Johanna Hünigen, Hana Richardson, Kenneth C. Gemeinhardt, Ole Niehues, Stefan M. PLoS One Research Article This study reports morphometric and age-related data of the mandibular canal and the alveolar ridge of the Göttingen Minipig to avoid complications during in vivo testing of endosseus dental implants and to compare these data with the human anatomy. Using 3D computed tomography, six parameters of the mandibular canal as well as the alveolar bone height and the alveolar ridge width were measured in Göttingen Minipigs aged 12, 17 and 21 months. Our null hypothesis assumes that the age and the body mass have an influence on the parameters measured. The study found that the volume, length and depth of the mandibular canal all increase with age. The width of the canal does not change significantly with age. The body mass does not have an influence on any of the measured parameters. The increase in canal volume appears to be due to loss of deep spongy bone in the posterior premolar and molar regions. This reduces the available space for dental implantations, negatively affecting implant stability and potentially the integrity of the inferior alveolar neurovascular bundle. Dynamic anatomical changes occur until 21 months. On ethical grounds, using minipigs younger than 21 months in experimental implant dentistry is inadvisable. Paradoxically the measurements of the 12 months old pigs indicate a closer alignment of their mandibular anatomy to that of humans suggesting that they may be better models for implant studies. Given the variability in mandibular canal dimensions in similar age cohorts, the use of imaging techniques is essential for the selection of individual minipigs for dental prosthetic interventions and thus higher success rates. Public Library of Science 2017-09-14 /pmc/articles/PMC5599038/ /pubmed/28910382 http://dx.doi.org/10.1371/journal.pone.0184889 Text en © 2017 Corte et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Corte, Giuliano M.
Plendl, Johanna
Hünigen, Hana
Richardson, Kenneth C.
Gemeinhardt, Ole
Niehues, Stefan M.
Refining experimental dental implant testing in the Göttingen Minipig using 3D computed tomography—A morphometric study of the mandibular canal
title Refining experimental dental implant testing in the Göttingen Minipig using 3D computed tomography—A morphometric study of the mandibular canal
title_full Refining experimental dental implant testing in the Göttingen Minipig using 3D computed tomography—A morphometric study of the mandibular canal
title_fullStr Refining experimental dental implant testing in the Göttingen Minipig using 3D computed tomography—A morphometric study of the mandibular canal
title_full_unstemmed Refining experimental dental implant testing in the Göttingen Minipig using 3D computed tomography—A morphometric study of the mandibular canal
title_short Refining experimental dental implant testing in the Göttingen Minipig using 3D computed tomography—A morphometric study of the mandibular canal
title_sort refining experimental dental implant testing in the göttingen minipig using 3d computed tomography—a morphometric study of the mandibular canal
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599038/
https://www.ncbi.nlm.nih.gov/pubmed/28910382
http://dx.doi.org/10.1371/journal.pone.0184889
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