Polymicrobial sepsis impairs bystander recruitment of effector cells to infected skin despite optimal sensing and alarming function of skin resident memory CD8 T cells

Sepsis is a systemic infection that enhances host vulnerability to secondary infections normally controlled by T cells. Using CLP sepsis model, we observed that sepsis induces apoptosis of circulating memory CD8 T-cells (T(CIRCM)) and diminishes their effector functions, leading to impaired CD8 T-ce...

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Detalles Bibliográficos
Autores principales: Danahy, Derek B., Anthony, Scott M., Jensen, Isaac J., Hartwig, Stacey M., Shan, Qiang, Xue, Hai-Hui, Harty, John T., Griffith, Thomas S., Badovinac, Vladimir P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599054/
https://www.ncbi.nlm.nih.gov/pubmed/28910403
http://dx.doi.org/10.1371/journal.ppat.1006569

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599054/
https://www.ncbi.nlm.nih.gov/pubmed/28910403
http://dx.doi.org/10.1371/journal.ppat.1006569

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