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5C analysis of the Epidermal Differentiation Complex locus reveals distinct chromatin interaction networks between gene-rich and gene-poor TADs in skin epithelial cells
Mammalian genomes contain several dozens of large (>0.5 Mbp) lineage-specific gene loci harbouring functionally related genes. However, spatial chromatin folding, organization of the enhancer-promoter networks and their relevance to Topologically Associating Domains (TADs) in these loci remain po...
Autores principales: | Poterlowicz, Krzysztof, Yarker, Joanne L., Malashchuk, Igor, Lajoie, Brian R., Mardaryev, Andrei N., Gdula, Michal R., Sharov, Andrey A., Kohwi-Shigematsu, Terumi, Botchkarev, Vladimir A., Fessing, Michael Y. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599062/ https://www.ncbi.nlm.nih.gov/pubmed/28863138 http://dx.doi.org/10.1371/journal.pgen.1006966 |
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