Tadalafil has biologic activity in human melanoma. Results of a pilot trial with Tadalafil in patients with metastatic Melanoma (TaMe)

Myeloid-derived suppressor cells (MDSCs) are known to play a critical role in the suppression of T cell antitumor responses. Our preclinical data showed that the phosphodiesterase (PDE)-5 inhibitor sildenafil impaired MDSC functions, enhanced intratumoral T cell activity and prolonged survival of me...

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Detalles Bibliográficos
Autores principales: Hassel, Jessica C., Jiang, Huanhuan, Bender, Carolin, Winkler, Julia, Sevko, Alexandra, Shevchenko, Ivan, Halama, Niels, Dimitrakopoulou-Strauss, Antonia, Haefeli, Walter E., Jäger, Dirk, Enk, Alexander, Utikal, Jochen, Umansky, Viktor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599085/
https://www.ncbi.nlm.nih.gov/pubmed/28932631
http://dx.doi.org/10.1080/2162402X.2017.1326440

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