Cargando…
Cancer stem cell signaling pathways
Tissue development and homeostasis are governed by the actions of stem cells. Multipotent cells are capable of self-renewal during the course of one's lifetime. The accurate and appropriate regulation of stem cell functions is absolutely critical for normal biological activity. Several key deve...
Autor principal: | |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599211/ https://www.ncbi.nlm.nih.gov/pubmed/27611937 http://dx.doi.org/10.1097/MD.0000000000004765 |
_version_ | 1783264041609723904 |
---|---|
author | Matsui, William H. |
author_facet | Matsui, William H. |
author_sort | Matsui, William H. |
collection | PubMed |
description | Tissue development and homeostasis are governed by the actions of stem cells. Multipotent cells are capable of self-renewal during the course of one's lifetime. The accurate and appropriate regulation of stem cell functions is absolutely critical for normal biological activity. Several key developmental or signaling pathways have been shown to play essential roles in this regulatory capacity. Specifically, the Janus-activated kinase/signal transducer and activator of transcription, Hedgehog, Wnt, Notch, phosphatidylinositol 3-kinase/phosphatase and tensin homolog, and nuclear factor-κB signaling pathways have all been shown experimentally to mediate various stem cell properties, such as self-renewal, cell fate decisions, survival, proliferation, and differentiation. Unsurprisingly, many of these crucial signaling pathways are dysregulated in cancer. Growing evidence suggests that overactive or abnormal signaling within and among these pathways may contribute to the survival of cancer stem cells (CSCs). CSCs are a relatively rare population of cancer cells capable of self-renewal, differentiation, and generation of serially transplantable heterogeneous tumors of several types of cancer. |
format | Online Article Text |
id | pubmed-5599211 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-55992112017-09-18 Cancer stem cell signaling pathways Matsui, William H. Medicine (Baltimore) 5700 Tissue development and homeostasis are governed by the actions of stem cells. Multipotent cells are capable of self-renewal during the course of one's lifetime. The accurate and appropriate regulation of stem cell functions is absolutely critical for normal biological activity. Several key developmental or signaling pathways have been shown to play essential roles in this regulatory capacity. Specifically, the Janus-activated kinase/signal transducer and activator of transcription, Hedgehog, Wnt, Notch, phosphatidylinositol 3-kinase/phosphatase and tensin homolog, and nuclear factor-κB signaling pathways have all been shown experimentally to mediate various stem cell properties, such as self-renewal, cell fate decisions, survival, proliferation, and differentiation. Unsurprisingly, many of these crucial signaling pathways are dysregulated in cancer. Growing evidence suggests that overactive or abnormal signaling within and among these pathways may contribute to the survival of cancer stem cells (CSCs). CSCs are a relatively rare population of cancer cells capable of self-renewal, differentiation, and generation of serially transplantable heterogeneous tumors of several types of cancer. Wolters Kluwer Health 2016-01-08 /pmc/articles/PMC5599211/ /pubmed/27611937 http://dx.doi.org/10.1097/MD.0000000000004765 Text en Copyright © 2016 the Author. Published by Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially. http://creativecommons.org/licenses/by-nc/4.0 |
spellingShingle | 5700 Matsui, William H. Cancer stem cell signaling pathways |
title | Cancer stem cell signaling pathways |
title_full | Cancer stem cell signaling pathways |
title_fullStr | Cancer stem cell signaling pathways |
title_full_unstemmed | Cancer stem cell signaling pathways |
title_short | Cancer stem cell signaling pathways |
title_sort | cancer stem cell signaling pathways |
topic | 5700 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599211/ https://www.ncbi.nlm.nih.gov/pubmed/27611937 http://dx.doi.org/10.1097/MD.0000000000004765 |
work_keys_str_mv | AT matsuiwilliamh cancerstemcellsignalingpathways |