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Methylome Analysis of Human Bone Marrow MSCs Reveals Extensive Age- and Culture-Induced Changes at Distal Regulatory Elements

Human bone marrow stromal cells, or mesenchymal stem cells (BM-MSCs), need expansion prior to use as cell-based therapies in immunological and tissue repair applications. Aging and expansion of BM-MSCs induce epigenetic changes that can impact therapeutic outcomes. By applying sequencing-based metho...

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Detalles Bibliográficos
Autores principales:	Pasumarthy, Kalyan K., Doni Jayavelu, Naresh, Kilpinen, Lotta, Andrus, Colin, Battle, Stephanie L., Korhonen, Matti, Lehenkari, Petri, Lund, Riikka, Laitinen, Saara, Hawkins, R. David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2017
Materias:	Resource
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599244/ https://www.ncbi.nlm.nih.gov/pubmed/28844656 http://dx.doi.org/10.1016/j.stemcr.2017.07.018

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