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The interdependent network of gene regulation and metabolism is robust where it needs to be

Despite being highly interdependent, the major biochemical networks of the living cell—the networks of interacting genes and of metabolic reactions, respectively—have been approached mostly as separate systems so far. Recently, a framework for interdependent networks has emerged in the context of st...

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Autores principales: Klosik, David F., Grimbs, Anne, Bornholdt, Stefan, Hütt, Marc-Thorsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599549/
https://www.ncbi.nlm.nih.gov/pubmed/28912490
http://dx.doi.org/10.1038/s41467-017-00587-4
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author Klosik, David F.
Grimbs, Anne
Bornholdt, Stefan
Hütt, Marc-Thorsten
author_facet Klosik, David F.
Grimbs, Anne
Bornholdt, Stefan
Hütt, Marc-Thorsten
author_sort Klosik, David F.
collection PubMed
description Despite being highly interdependent, the major biochemical networks of the living cell—the networks of interacting genes and of metabolic reactions, respectively—have been approached mostly as separate systems so far. Recently, a framework for interdependent networks has emerged in the context of statistical physics. In a first quantitative application of this framework to systems biology, here we study the interdependent network of gene regulation and metabolism for the model organism Escherichia coli in terms of a biologically motivated percolation model. Particularly, we approach the system’s conflicting tasks of reacting rapidly to (internal and external) perturbations, while being robust to minor environmental fluctuations. Considering its response to perturbations that are localized with respect to functional criteria, we find the interdependent system to be sensitive to gene regulatory and protein-level perturbations, yet robust against metabolic changes. We expect this approach to be applicable to a range of other interdependent networks.
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spelling pubmed-55995492017-09-18 The interdependent network of gene regulation and metabolism is robust where it needs to be Klosik, David F. Grimbs, Anne Bornholdt, Stefan Hütt, Marc-Thorsten Nat Commun Article Despite being highly interdependent, the major biochemical networks of the living cell—the networks of interacting genes and of metabolic reactions, respectively—have been approached mostly as separate systems so far. Recently, a framework for interdependent networks has emerged in the context of statistical physics. In a first quantitative application of this framework to systems biology, here we study the interdependent network of gene regulation and metabolism for the model organism Escherichia coli in terms of a biologically motivated percolation model. Particularly, we approach the system’s conflicting tasks of reacting rapidly to (internal and external) perturbations, while being robust to minor environmental fluctuations. Considering its response to perturbations that are localized with respect to functional criteria, we find the interdependent system to be sensitive to gene regulatory and protein-level perturbations, yet robust against metabolic changes. We expect this approach to be applicable to a range of other interdependent networks. Nature Publishing Group UK 2017-09-14 /pmc/articles/PMC5599549/ /pubmed/28912490 http://dx.doi.org/10.1038/s41467-017-00587-4 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Klosik, David F.
Grimbs, Anne
Bornholdt, Stefan
Hütt, Marc-Thorsten
The interdependent network of gene regulation and metabolism is robust where it needs to be
title The interdependent network of gene regulation and metabolism is robust where it needs to be
title_full The interdependent network of gene regulation and metabolism is robust where it needs to be
title_fullStr The interdependent network of gene regulation and metabolism is robust where it needs to be
title_full_unstemmed The interdependent network of gene regulation and metabolism is robust where it needs to be
title_short The interdependent network of gene regulation and metabolism is robust where it needs to be
title_sort interdependent network of gene regulation and metabolism is robust where it needs to be
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599549/
https://www.ncbi.nlm.nih.gov/pubmed/28912490
http://dx.doi.org/10.1038/s41467-017-00587-4
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