PTPRJ Inhibits Leptin Signaling, and Induction of PTPRJ in the Hypothalamus Is a Cause of the Development of Leptin Resistance

Leptin signaling in the hypothalamus plays a crucial role in the regulation of body weight. Leptin resistance, in which leptin signaling is disrupted, is a major obstacle to the improvement of obesity. We herein demonstrated that protein tyrosine phosphatase receptor type J (Ptprj) is expressed in h...

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Detalles Bibliográficos
Autores principales: Shintani, Takafumi, Higashi, Satoru, Suzuki, Ryoko, Takeuchi, Yasushi, Ikaga, Reina, Yamazaki, Tomomi, Kobayashi, Kenta, Noda, Masaharu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599550/
https://www.ncbi.nlm.nih.gov/pubmed/28912580
http://dx.doi.org/10.1038/s41598-017-12070-7

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