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Y Chromosome, Mitochondrial DNA and Childhood Behavioural Traits

Many psychiatric traits are sexually dimorphic in terms of prevalence, age of onset, progression and prognosis; sex chromosomes could play a role in these differences. In this study we evaluated the association between Y chromosome and mitochondrial DNA haplogroups with sexually-dimorphic behavioura...

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Autores principales: Howe, Laurence J., Erzurumluoglu, A. Mesut, Davey Smith, George, Rodriguez, Santiago, Stergiakouli, Evie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599552/
https://www.ncbi.nlm.nih.gov/pubmed/28912458
http://dx.doi.org/10.1038/s41598-017-10871-4
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author Howe, Laurence J.
Erzurumluoglu, A. Mesut
Davey Smith, George
Rodriguez, Santiago
Stergiakouli, Evie
author_facet Howe, Laurence J.
Erzurumluoglu, A. Mesut
Davey Smith, George
Rodriguez, Santiago
Stergiakouli, Evie
author_sort Howe, Laurence J.
collection PubMed
description Many psychiatric traits are sexually dimorphic in terms of prevalence, age of onset, progression and prognosis; sex chromosomes could play a role in these differences. In this study we evaluated the association between Y chromosome and mitochondrial DNA haplogroups with sexually-dimorphic behavioural and psychiatric traits. The study sample included 4,211 males and 4,009 females with mitochondrial DNA haplogroups and 4,788 males with Y chromosome haplogroups who are part of the Avon Longitudinal Study of Parents and Children (ALSPAC) based in the United Kingdom. Different subsets of these populations were assessed using measures of behavioural and psychiatric traits with logistic regression being used to measure the association between haplogroups and the traits. The majority of behavioural traits in our cohort differed between males and females; however Y chromosome and mitochondrial DNA haplogroups were not associated with any of the variables. These findings suggest that if there is common variation on the Y chromosome and mitochondrial DNA associated with behavioural and psychiatric trait variation, it has a small effect.
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spelling pubmed-55995522017-09-15 Y Chromosome, Mitochondrial DNA and Childhood Behavioural Traits Howe, Laurence J. Erzurumluoglu, A. Mesut Davey Smith, George Rodriguez, Santiago Stergiakouli, Evie Sci Rep Article Many psychiatric traits are sexually dimorphic in terms of prevalence, age of onset, progression and prognosis; sex chromosomes could play a role in these differences. In this study we evaluated the association between Y chromosome and mitochondrial DNA haplogroups with sexually-dimorphic behavioural and psychiatric traits. The study sample included 4,211 males and 4,009 females with mitochondrial DNA haplogroups and 4,788 males with Y chromosome haplogroups who are part of the Avon Longitudinal Study of Parents and Children (ALSPAC) based in the United Kingdom. Different subsets of these populations were assessed using measures of behavioural and psychiatric traits with logistic regression being used to measure the association between haplogroups and the traits. The majority of behavioural traits in our cohort differed between males and females; however Y chromosome and mitochondrial DNA haplogroups were not associated with any of the variables. These findings suggest that if there is common variation on the Y chromosome and mitochondrial DNA associated with behavioural and psychiatric trait variation, it has a small effect. Nature Publishing Group UK 2017-09-14 /pmc/articles/PMC5599552/ /pubmed/28912458 http://dx.doi.org/10.1038/s41598-017-10871-4 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Howe, Laurence J.
Erzurumluoglu, A. Mesut
Davey Smith, George
Rodriguez, Santiago
Stergiakouli, Evie
Y Chromosome, Mitochondrial DNA and Childhood Behavioural Traits
title Y Chromosome, Mitochondrial DNA and Childhood Behavioural Traits
title_full Y Chromosome, Mitochondrial DNA and Childhood Behavioural Traits
title_fullStr Y Chromosome, Mitochondrial DNA and Childhood Behavioural Traits
title_full_unstemmed Y Chromosome, Mitochondrial DNA and Childhood Behavioural Traits
title_short Y Chromosome, Mitochondrial DNA and Childhood Behavioural Traits
title_sort y chromosome, mitochondrial dna and childhood behavioural traits
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599552/
https://www.ncbi.nlm.nih.gov/pubmed/28912458
http://dx.doi.org/10.1038/s41598-017-10871-4
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