Caloric restriction delays age-related methylation drift

In mammals, caloric restriction consistently results in extended lifespan. Epigenetic information encoded by DNA methylation is tightly regulated, but shows a striking drift associated with age that includes both gains and losses of DNA methylation at various sites. Here, we report that epigenetic d...

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Detalles Bibliográficos
Autores principales: Maegawa, Shinji, Lu, Yue, Tahara, Tomomitsu, Lee, Justin T., Madzo, Jozef, Liang, Shoudan, Jelinek, Jaroslav, Colman, Ricki J., Issa, Jean-Pierre J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599616/
https://www.ncbi.nlm.nih.gov/pubmed/28912502
http://dx.doi.org/10.1038/s41467-017-00607-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599616/
https://www.ncbi.nlm.nih.gov/pubmed/28912502
http://dx.doi.org/10.1038/s41467-017-00607-3

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