Cargando…

Selective antibody activation through protease-activated pro-antibodies that mask binding sites with inhibitory domains

Systemic injection of therapeutic antibodies may cause serious adverse effects due to on-target toxicity to the antigens expressed in normal tissues. To improve the targeting selectivity to the region of disease sites, we developed protease-activated pro-antibodies by masking the binding sites of an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, I-Ju, Chuang, Chih-Hung, Hsieh, Yuan-Chin, Lu, Yun-Chi, Lin, Wen-Wei, Huang, Chien-Chiao, Cheng, Ta-Chun, Cheng, Yi-An, Cheng, Kai-Wen, Wang, Yeng-Tseng, Chen, Fang-Ming, Cheng, Tian-Lu, Tzou, Shey-Cherng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599682/ https://www.ncbi.nlm.nih.gov/pubmed/28912497 http://dx.doi.org/10.1038/s41598-017-11886-7

Ejemplares similares

Functional Production of a Soluble and Secreted Single-Chain Antibody by a Bacterial Secretion System
por: Cheng, Chiu-Min, et al.
Publicado: (2014)

Development of a structure-based computational simulation to optimize the blocking efficacy of pro-antibodies
por: Huang, Bo-Cheng, et al.
Publicado: (2021)

Correction: Development of a structure-based computational simulation to optimize the blocking efficacy of pro-antibodies
por: Huang, Bo-Cheng, et al.
Publicado: (2021)

Selective activation of pro-anti-IL-1β antibody enhances specificity for autoinflammatory disorder therapy
por: Lin, Wen-Wei, et al.
Publicado: (2021)

A Secondary Antibody-Detecting Molecular Weight Marker with Mouse and Rabbit IgG Fc Linear Epitopes for Western Blot Analysis
por: Lin, Wen-Wei, et al.
Publicado: (2016)

Discovery of Akt Kinase Inhibitors through Structure-Based Virtual Screening and Their Evaluation as Potential Anticancer Agents
por: Chuang, Chih-Hung, et al.
Publicado: (2015)

In Situ Activation of Pituitary-Infiltrating T Lymphocytes in Autoimmune Hypophysitis
por: Lin, Han-Huei, et al.
Publicado: (2017)

Specific activation of pro-Infliximab enhances selectivity and safety of rheumatoid arthritis therapy
por: Lu, Yun-Chi, et al.
Publicado: (2019)

Selectivity Conversion of Protease Inhibitory Antibodies
por: Lopez, Tyler, et al.
Publicado: (2018)

Protease-Activation of Fc-Masked Therapeutic Antibodies to Alleviate Off-Tumor Cytotoxicity
por: Elter, Adrian, et al.
Publicado: (2021)

Development of an Albumin-Masked mutPD-1Ig as a Tumor Lesion-Selective Immune Checkpoint Inhibitor
por: Chou, Chien-Yu, et al.
Publicado: (2023)

Ab locks for improving the selectivity and safety of antibody drugs
por: Lin, Wen-Wei, et al.
Publicado: (2020)

Use of syngeneic cells expressing membrane-bound GM-CSF as an adjuvant to induce antibodies against native multi-pass transmembrane protein
por: Huang, Chien-Chiao, et al.
Publicado: (2019)

Structural and functional characterization of MERS coronavirus papain-like protease
por: Lin, Min-Han, et al.
Publicado: (2014)

Anti-Spike Antibody Response to Natural Infection with SARS-CoV-2 and Its Activity against Emerging Variants
por: Chen, Cheng-Pin, et al.
Publicado: (2022)

Anti–Cyclic Citrullinated Peptide Antibodies Correlate to Ultrasound Synovitis in Rheumatoid Arthritis Better Than C-Reactive Protein
por: Lu, Cheng-Hsun, et al.
Publicado: (2021)

Micro-PET imaging of hepatitis C virus NS3/4A protease activity using a protease-activatable retention probe
por: Chuang, Chih-Hung, et al.
Publicado: (2022)

Using anti-poly(ethylene glycol) bioparticles for the quantitation of PEGylated nanoparticles
por: Hsieh, Yuan-Chin, et al.
Publicado: (2016)

Double attack strategy for leukemia using a pre-targeting bispecific antibody (CD20 Ab-mPEG scFv) and actively attracting PEGylated liposomal doxorubicin to enhance anti-tumor activity
por: Ho, Kai-Wen, et al.
Publicado: (2021)

Fibrinogen-Like Protein 1 Serves as an Anti-Inflammatory Agent for Collagen-Induced Arthritis Therapy in Mice
por: Lin, Wen-Wei, et al.
Publicado: (2021)

Anti-TNF Alpha Antibody Humira with pH-dependent Binding Characteristics: A constant-pH Molecular Dynamics, Gaussian Accelerated Molecular Dynamics, and In Vitro Study
por: Hong, Shih-Ting, et al.
Publicado: (2021)

Pre-existing anti-polyethylene glycol antibody reduces the therapeutic efficacy and pharmacokinetics of PEGylated liposomes
por: Hsieh, Yuan-Chin, et al.
Publicado: (2018)

A universal in silico V(D)J recombination strategy for developing humanized monoclonal antibodies
por: Hsieh, Yuan-Chin, et al.
Publicado: (2022)

Protease-activation using anti-idiotypic masks enables tumor specificity of a folate receptor 1-T cell bispecific antibody
por: Geiger, Martina, et al.
Publicado: (2020)

STUDIES ON THE ACTIVATION OF SERUM PROTEASE BY AN ANTIGEN-ANTIBODY SYSTEM
por: Jemski, Joseph V., et al.
Publicado: (1953)

Development of NS2B-NS3 protease inhibitor that impairs Zika virus replication()
por: Lin, Wen-Wei, et al.
Publicado: (2023)

Thiopurine analogs and mycophenolic acid synergistically inhibit the papain-like protease of Middle East respiratory syndrome coronavirus
por: Cheng, Kai-Wen, et al.
Publicado: (2015)

Characterization of trans‐ and cis‐cleavage activity of the SARS coronavirus 3CL(pro) protease: basis for the in vitro screening of anti‐SARS drugs
por: Lin, Cheng-Wen, et al.
Publicado: (2004)

Binding interaction of SARS coronavirus 3CL(pro) protease with vacuolar‐H(+) ATPase G1 subunit
por: Lin, Cheng-Wen, et al.
Publicado: (2005)

A non-genetic engineering platform for rapidly generating and expanding cancer-specific armed T cells
por: Chen, Yi-Jou, et al.
Publicado: (2023)

High-Throughput Sorting of the Highest Producing Cell via a Transiently Protein-Anchored System
por: Chuang, Kuo-Hsiang, et al.
Publicado: (2014)

FlipGFP protease assay for evaluating in vitro inhibitory activity against SARS-CoV-2 M(pro) and PL(pro)
por: Tan, Haozhou, et al.
Publicado: (2023)

Antibodies to Serine Proteases in the Antiphospholipid Syndrome
por: Chen, Pojen P., et al.
Publicado: (2010)

Antibodies against the SARS-CoV-2 S1-RBD cross-react with dengue virus and hinder dengue pathogenesis
por: Cheng, Yi-Ling, et al.
Publicado: (2022)

Quantitative Systems Pharmacology Model of a Masked, Tumor‐Activated Antibody
por: Stroh, Mark, et al.
Publicado: (2019)

Cyclic Peptide Inhibitors of the Tsg101 UEV Protein Interactions Refined through Global Docking and Gaussian Accelerated Molecular Dynamics Simulations
por: Lin, Wen-Wei, et al.
Publicado: (2020)

Fumarate hydratase inhibits non-small cell lung cancer metastasis via inactivation of AMPK and upregulation of DAB2
por: Vadhan, Anupama, et al.
Publicado: (2022)

Molecular interaction of the antiviral compound CW-33 and its analogues with the NS2B-NS3 protease of the Japanese encephalitis virus
por: Chen, Kuan-Chung, et al.
Publicado: (2019)

Enhancement of tumor tropism of mPEGylated nanoparticles by anti-mPEG bispecific antibody for ovarian cancer therapy
por: Lin, Wen-Wei, et al.
Publicado: (2021)

Multicenter evaluation of four immunoassays for the performance of early diagnosis of COVID-19 and assessment of antibody responses of patients with pneumonia in Taiwan
por: Lin, Yi-Chun, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_i98tsnj5ol0qnn2pp3n9aki5kd