Cross-Linking of a CD4-Mimetic Miniprotein with HIV-1 Env gp140 Alters Kinetics and Specificities of Antibody Responses against HIV-1 Env in Macaques

Evaluation of the epitope specificities, locations (systemic or mucosal), and effector functions of antibodies elicited by novel HIV-1 immunogens engineered to improve exposure of specific epitopes is critical for HIV-1 vaccine development. Utilizing an array of humoral assays, we evaluated the magn...

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Detalles Bibliográficos
Autores principales: Shen, Xiaoying, Bogers, Willy M., Yates, Nicole L., Ferrari, Guido, Dey, Antu K., Williams, William T., Jaeger, Frederick H., Wiehe, Kevin, Sawant, Sheetal, Alam, S. Munir, LaBranche, Celia C., Montefiori, David C., Martin, Loic, Srivastava, Indresh, Heeney, Jonathan, Barnett, Susan W., Tomaras, Georgia D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Vaccines and Antiviral Agents
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599731/
https://www.ncbi.nlm.nih.gov/pubmed/28490585
http://dx.doi.org/10.1128/JVI.00401-17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599731/
https://www.ncbi.nlm.nih.gov/pubmed/28490585
http://dx.doi.org/10.1128/JVI.00401-17

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