Increased, Durable B-Cell and ADCC Responses Associated with T-Helper Cell Responses to HIV-1 Envelope in Macaques Vaccinated with gp140 Occluded at the CD4 Receptor Binding Site

Strategies are needed to improve the immunogenicity of HIV-1 envelope (Env) antigens (Ag) for more long-lived, efficacious HIV-1 vaccine-induced B-cell responses. HIV-1 Env gp140 (native or uncleaved molecules) or gp120 monomeric proteins elicit relatively poor B-cell responses which are short-lived...

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Detalles Bibliográficos
Autores principales: Bogers, Willy M. J. M., Barnett, Susan W., Oostermeijer, Herman, Nieuwenhuis, Ivonne G., Beenhakker, Niels, Mortier, Daniella, Mooij, Petra, Koopman, Gerrit, Remarque, Edmund, Martin, Gregoire, Lai, Rachel Pei-Jen, Dey, Antu K., Sun, Yide, Burke, Brian, Ferrari, Guido, Montefiori, David, Martin, Loic, Davis, David, Srivastava, Indresh, Heeney, Jonathan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Vaccines and Antiviral Agents
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599767/
https://www.ncbi.nlm.nih.gov/pubmed/28701402
http://dx.doi.org/10.1128/JVI.00811-17

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