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Linker Histone in Diseases
The linker histone is a protein that binds with the nucleosome, which is generally considered to achieve chromatin condensation in the nucleus. Accumulating evidences suggest that the linker histone is essential in the pathogenesis of several diseases. In this review, we briefly introduce the curren...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599906/ https://www.ncbi.nlm.nih.gov/pubmed/28924382 http://dx.doi.org/10.7150/ijbs.19891 |
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author | Ye, Xin Feng, ChuanLin Gao, Tian Mu, Guanqun Zhu, Weiguo Yang, Yang |
author_facet | Ye, Xin Feng, ChuanLin Gao, Tian Mu, Guanqun Zhu, Weiguo Yang, Yang |
author_sort | Ye, Xin |
collection | PubMed |
description | The linker histone is a protein that binds with the nucleosome, which is generally considered to achieve chromatin condensation in the nucleus. Accumulating evidences suggest that the linker histone is essential in the pathogenesis of several diseases. In this review, we briefly introduce the current knowledge of the linker histone, including its structure, characteristics and functions. Also, we move forward to present the advances of the linker histone's association with certain diseases, such as cancer, Alzheimer's disease, infection, male infertility and aberrant immunity situations, focusing on the alteration of the linker histone under certain pathological conditions and its role in developing each disease. |
format | Online Article Text |
id | pubmed-5599906 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-55999062017-09-18 Linker Histone in Diseases Ye, Xin Feng, ChuanLin Gao, Tian Mu, Guanqun Zhu, Weiguo Yang, Yang Int J Biol Sci Review The linker histone is a protein that binds with the nucleosome, which is generally considered to achieve chromatin condensation in the nucleus. Accumulating evidences suggest that the linker histone is essential in the pathogenesis of several diseases. In this review, we briefly introduce the current knowledge of the linker histone, including its structure, characteristics and functions. Also, we move forward to present the advances of the linker histone's association with certain diseases, such as cancer, Alzheimer's disease, infection, male infertility and aberrant immunity situations, focusing on the alteration of the linker histone under certain pathological conditions and its role in developing each disease. Ivyspring International Publisher 2017-07-18 /pmc/articles/PMC5599906/ /pubmed/28924382 http://dx.doi.org/10.7150/ijbs.19891 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Review Ye, Xin Feng, ChuanLin Gao, Tian Mu, Guanqun Zhu, Weiguo Yang, Yang Linker Histone in Diseases |
title | Linker Histone in Diseases |
title_full | Linker Histone in Diseases |
title_fullStr | Linker Histone in Diseases |
title_full_unstemmed | Linker Histone in Diseases |
title_short | Linker Histone in Diseases |
title_sort | linker histone in diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599906/ https://www.ncbi.nlm.nih.gov/pubmed/28924382 http://dx.doi.org/10.7150/ijbs.19891 |
work_keys_str_mv | AT yexin linkerhistoneindiseases AT fengchuanlin linkerhistoneindiseases AT gaotian linkerhistoneindiseases AT muguanqun linkerhistoneindiseases AT zhuweiguo linkerhistoneindiseases AT yangyang linkerhistoneindiseases |