Structural Maintenance of Chromosomes protein 1: Role in Genome Stability and Tumorigenesis

SMC1 (Structural Maintenance of Chromosomes protein 1), well known as one of the SMC superfamily members, has been explored to function in many activities including chromosome dynamics, cell cycle checkpoint, DNA damage repair and genome stability. Upon being properly assembled as part of cohesin, S...

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Detalles Bibliográficos
Autores principales: Yi, Fei, Wang, Zhuo, Liu, Jingwei, Zhang, Ying, Wang, Zhijun, Xu, Hongde, Li, Xiaoman, Bai, Ning, Cao, Liu, Song, Xiaoyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599913/
https://www.ncbi.nlm.nih.gov/pubmed/28924389
http://dx.doi.org/10.7150/ijbs.21206
Descripción
Sumario:SMC1 (Structural Maintenance of Chromosomes protein 1), well known as one of the SMC superfamily members, has been explored to function in many activities including chromosome dynamics, cell cycle checkpoint, DNA damage repair and genome stability. Upon being properly assembled as part of cohesin, SMC1 can be phosphorylated by ATM and mediate downstream DNA damage repair after ionizing irradiation. Abnormal gene expression or mutation of SMC1 can cause defect in the DNA damage repair pathway, which has been strongly associated with tumorigenesis. Here we focus to discuss SMC1's role in genome stability maintenance and tumorigenesis. Deciphering the underlying molecular mechanism can provide insight into novel strategies for cancer treatment.

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