Structural Maintenance of Chromosomes protein 1: Role in Genome Stability and Tumorigenesis

SMC1 (Structural Maintenance of Chromosomes protein 1), well known as one of the SMC superfamily members, has been explored to function in many activities including chromosome dynamics, cell cycle checkpoint, DNA damage repair and genome stability. Upon being properly assembled as part of cohesin, S...

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Autores principales: Yi, Fei, Wang, Zhuo, Liu, Jingwei, Zhang, Ying, Wang, Zhijun, Xu, Hongde, Li, Xiaoman, Bai, Ning, Cao, Liu, Song, Xiaoyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599913/
https://www.ncbi.nlm.nih.gov/pubmed/28924389
http://dx.doi.org/10.7150/ijbs.21206
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author Yi, Fei
Wang, Zhuo
Liu, Jingwei
Zhang, Ying
Wang, Zhijun
Xu, Hongde
Li, Xiaoman
Bai, Ning
Cao, Liu
Song, Xiaoyu
author_facet Yi, Fei
Wang, Zhuo
Liu, Jingwei
Zhang, Ying
Wang, Zhijun
Xu, Hongde
Li, Xiaoman
Bai, Ning
Cao, Liu
Song, Xiaoyu
author_sort Yi, Fei
collection PubMed
description SMC1 (Structural Maintenance of Chromosomes protein 1), well known as one of the SMC superfamily members, has been explored to function in many activities including chromosome dynamics, cell cycle checkpoint, DNA damage repair and genome stability. Upon being properly assembled as part of cohesin, SMC1 can be phosphorylated by ATM and mediate downstream DNA damage repair after ionizing irradiation. Abnormal gene expression or mutation of SMC1 can cause defect in the DNA damage repair pathway, which has been strongly associated with tumorigenesis. Here we focus to discuss SMC1's role in genome stability maintenance and tumorigenesis. Deciphering the underlying molecular mechanism can provide insight into novel strategies for cancer treatment.
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spelling pubmed-55999132017-09-18 Structural Maintenance of Chromosomes protein 1: Role in Genome Stability and Tumorigenesis Yi, Fei Wang, Zhuo Liu, Jingwei Zhang, Ying Wang, Zhijun Xu, Hongde Li, Xiaoman Bai, Ning Cao, Liu Song, Xiaoyu Int J Biol Sci Review SMC1 (Structural Maintenance of Chromosomes protein 1), well known as one of the SMC superfamily members, has been explored to function in many activities including chromosome dynamics, cell cycle checkpoint, DNA damage repair and genome stability. Upon being properly assembled as part of cohesin, SMC1 can be phosphorylated by ATM and mediate downstream DNA damage repair after ionizing irradiation. Abnormal gene expression or mutation of SMC1 can cause defect in the DNA damage repair pathway, which has been strongly associated with tumorigenesis. Here we focus to discuss SMC1's role in genome stability maintenance and tumorigenesis. Deciphering the underlying molecular mechanism can provide insight into novel strategies for cancer treatment. Ivyspring International Publisher 2017-09-03 /pmc/articles/PMC5599913/ /pubmed/28924389 http://dx.doi.org/10.7150/ijbs.21206 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Yi, Fei
Wang, Zhuo
Liu, Jingwei
Zhang, Ying
Wang, Zhijun
Xu, Hongde
Li, Xiaoman
Bai, Ning
Cao, Liu
Song, Xiaoyu
Structural Maintenance of Chromosomes protein 1: Role in Genome Stability and Tumorigenesis
title Structural Maintenance of Chromosomes protein 1: Role in Genome Stability and Tumorigenesis
title_full Structural Maintenance of Chromosomes protein 1: Role in Genome Stability and Tumorigenesis
title_fullStr Structural Maintenance of Chromosomes protein 1: Role in Genome Stability and Tumorigenesis
title_full_unstemmed Structural Maintenance of Chromosomes protein 1: Role in Genome Stability and Tumorigenesis
title_short Structural Maintenance of Chromosomes protein 1: Role in Genome Stability and Tumorigenesis
title_sort structural maintenance of chromosomes protein 1: role in genome stability and tumorigenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599913/
https://www.ncbi.nlm.nih.gov/pubmed/28924389
http://dx.doi.org/10.7150/ijbs.21206
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