Recent advances in managing gastrointestinal stromal tumor

Constitutive activating mutations in KIT and platelet-derived growth factor receptor α ( PDGFRα) are heavily involved in the pathobiology of gastrointestinal stromal tumors (GISTs). This disease has served as an effective “proof-of-concept” model for targeting gain-of-function kinase mutations in ca...

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Detalles Bibliográficos
Autores principales: Duffaud, Florence, Le Cesne, Axel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000Research 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600003/
https://www.ncbi.nlm.nih.gov/pubmed/28928967
http://dx.doi.org/10.12688/f1000research.11118.1
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author Duffaud, Florence
Le Cesne, Axel
author_facet Duffaud, Florence
Le Cesne, Axel
author_sort Duffaud, Florence
collection PubMed
description Constitutive activating mutations in KIT and platelet-derived growth factor receptor α ( PDGFRα) are heavily involved in the pathobiology of gastrointestinal stromal tumors (GISTs). This disease has served as an effective “proof-of-concept” model for targeting gain-of-function kinase mutations in cancer. This review discusses the current standard of care in terms of pharmacotherapy in the management of localized and metastatic GISTs.
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spelling pubmed-56000032017-09-18 Recent advances in managing gastrointestinal stromal tumor Duffaud, Florence Le Cesne, Axel F1000Res Review Constitutive activating mutations in KIT and platelet-derived growth factor receptor α ( PDGFRα) are heavily involved in the pathobiology of gastrointestinal stromal tumors (GISTs). This disease has served as an effective “proof-of-concept” model for targeting gain-of-function kinase mutations in cancer. This review discusses the current standard of care in terms of pharmacotherapy in the management of localized and metastatic GISTs. F1000Research 2017-09-14 /pmc/articles/PMC5600003/ /pubmed/28928967 http://dx.doi.org/10.12688/f1000research.11118.1 Text en Copyright: © 2017 Duffaud F and Le Cesne A http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Duffaud, Florence
Le Cesne, Axel
Recent advances in managing gastrointestinal stromal tumor
title Recent advances in managing gastrointestinal stromal tumor
title_full Recent advances in managing gastrointestinal stromal tumor
title_fullStr Recent advances in managing gastrointestinal stromal tumor
title_full_unstemmed Recent advances in managing gastrointestinal stromal tumor
title_short Recent advances in managing gastrointestinal stromal tumor
title_sort recent advances in managing gastrointestinal stromal tumor
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600003/
https://www.ncbi.nlm.nih.gov/pubmed/28928967
http://dx.doi.org/10.12688/f1000research.11118.1
work_keys_str_mv AT duffaudflorence recentadvancesinmanaginggastrointestinalstromaltumor
AT lecesneaxel recentadvancesinmanaginggastrointestinalstromaltumor

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