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MR Spectroscopy to Distinguish between Supratentorial Intraventricular Subependymoma and Central Neurocytoma
PURPOSE: The purpose of this study was to discriminate supratentorial intraventricular subependymoma (SIS) from central neurocytoma (CNC) using magnetic resonance spectroscopy (MRS). METHODS: Single-voxel proton MRS using a 1.5T or 3T MR scanner from five SISs, five CNCs, and normal controls were ev...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Japanese Society for Magnetic Resonance in Medicine
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600029/ https://www.ncbi.nlm.nih.gov/pubmed/27941295 http://dx.doi.org/10.2463/mrms.mp.2015-0013 |
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author | Ueda, Fumiaki Aburano, Hiroyuki Ryu, Yasuji Yoshie, Yuichi Nakada, Mitsutoshi Hayashi, Yutaka Matsui, Osamu Gabata, Toshifumi |
author_facet | Ueda, Fumiaki Aburano, Hiroyuki Ryu, Yasuji Yoshie, Yuichi Nakada, Mitsutoshi Hayashi, Yutaka Matsui, Osamu Gabata, Toshifumi |
author_sort | Ueda, Fumiaki |
collection | PubMed |
description | PURPOSE: The purpose of this study was to discriminate supratentorial intraventricular subependymoma (SIS) from central neurocytoma (CNC) using magnetic resonance spectroscopy (MRS). METHODS: Single-voxel proton MRS using a 1.5T or 3T MR scanner from five SISs, five CNCs, and normal controls were evaluated. They were examined using a point-resolved spectroscopy. Automatically calculated ratios comparing choline (Cho), N-acetylaspartate (NAA), myoinositol (MI), and/or glycine (Gly) to creatine (Cr) were determined. Evaluation of Cr to unsuppressed water (USW) was also performed. Mann-Whitney U test was carried out to test the significance of differences in the metabolite ratios. Detectability of lactate (Lac) and alanine (Ala) was evaluated. RESULTS: Although a statistically significant difference (P < 0.0001) was observed in Cho/Cr among SIS, control spectra, and CNC, no statistical difference was noted between SIS and control spectra (P = 0.11). Statistically significant differences were observed in NAA/Cr between SIS and CNC (P = 0.04) or control spectra (P < 0.0001). A statistically significant difference was observed in MI and/or Gly to Cr between SIS and control spectra (P = 0.03), and CNC and control spectra (P < 0.0006). There were no statistical differences between SIS and CNC for MI and/or Gly to Cr (P = 0.32). Significant statistical differences were found between SIS and control spectra (P < 0.0053), control spectra and CNC (P < 0.0016), and SIS and CNC (P < 0.0083) for Cr to USW. Lac inverted doublets were confirmed in two SISs. Triplets of Lac and Ala were detected in four spectra of CNC. CONCLUSION: The present study showed that MRS can be useful in discriminating SIS from CNC. |
format | Online Article Text |
id | pubmed-5600029 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Japanese Society for Magnetic Resonance in Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-56000292017-10-23 MR Spectroscopy to Distinguish between Supratentorial Intraventricular Subependymoma and Central Neurocytoma Ueda, Fumiaki Aburano, Hiroyuki Ryu, Yasuji Yoshie, Yuichi Nakada, Mitsutoshi Hayashi, Yutaka Matsui, Osamu Gabata, Toshifumi Magn Reson Med Sci Major Paper PURPOSE: The purpose of this study was to discriminate supratentorial intraventricular subependymoma (SIS) from central neurocytoma (CNC) using magnetic resonance spectroscopy (MRS). METHODS: Single-voxel proton MRS using a 1.5T or 3T MR scanner from five SISs, five CNCs, and normal controls were evaluated. They were examined using a point-resolved spectroscopy. Automatically calculated ratios comparing choline (Cho), N-acetylaspartate (NAA), myoinositol (MI), and/or glycine (Gly) to creatine (Cr) were determined. Evaluation of Cr to unsuppressed water (USW) was also performed. Mann-Whitney U test was carried out to test the significance of differences in the metabolite ratios. Detectability of lactate (Lac) and alanine (Ala) was evaluated. RESULTS: Although a statistically significant difference (P < 0.0001) was observed in Cho/Cr among SIS, control spectra, and CNC, no statistical difference was noted between SIS and control spectra (P = 0.11). Statistically significant differences were observed in NAA/Cr between SIS and CNC (P = 0.04) or control spectra (P < 0.0001). A statistically significant difference was observed in MI and/or Gly to Cr between SIS and control spectra (P = 0.03), and CNC and control spectra (P < 0.0006). There were no statistical differences between SIS and CNC for MI and/or Gly to Cr (P = 0.32). Significant statistical differences were found between SIS and control spectra (P < 0.0053), control spectra and CNC (P < 0.0016), and SIS and CNC (P < 0.0083) for Cr to USW. Lac inverted doublets were confirmed in two SISs. Triplets of Lac and Ala were detected in four spectra of CNC. CONCLUSION: The present study showed that MRS can be useful in discriminating SIS from CNC. Japanese Society for Magnetic Resonance in Medicine 2016-12-12 /pmc/articles/PMC5600029/ /pubmed/27941295 http://dx.doi.org/10.2463/mrms.mp.2015-0013 Text en © 2016 Japanese Society for Magnetic Resonance in Medicine This is an open-access article. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/ |
spellingShingle | Major Paper Ueda, Fumiaki Aburano, Hiroyuki Ryu, Yasuji Yoshie, Yuichi Nakada, Mitsutoshi Hayashi, Yutaka Matsui, Osamu Gabata, Toshifumi MR Spectroscopy to Distinguish between Supratentorial Intraventricular Subependymoma and Central Neurocytoma |
title | MR Spectroscopy to Distinguish between Supratentorial Intraventricular Subependymoma and Central Neurocytoma |
title_full | MR Spectroscopy to Distinguish between Supratentorial Intraventricular Subependymoma and Central Neurocytoma |
title_fullStr | MR Spectroscopy to Distinguish between Supratentorial Intraventricular Subependymoma and Central Neurocytoma |
title_full_unstemmed | MR Spectroscopy to Distinguish between Supratentorial Intraventricular Subependymoma and Central Neurocytoma |
title_short | MR Spectroscopy to Distinguish between Supratentorial Intraventricular Subependymoma and Central Neurocytoma |
title_sort | mr spectroscopy to distinguish between supratentorial intraventricular subependymoma and central neurocytoma |
topic | Major Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600029/ https://www.ncbi.nlm.nih.gov/pubmed/27941295 http://dx.doi.org/10.2463/mrms.mp.2015-0013 |
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