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Diagnostic Performance of Diffusion Tensor Imaging with Readout-segmented Echo-planar Imaging for Invasive Breast Cancer: Correlation of ADC and FA with Pathological Prognostic Markers
PURPOSE: To assess the diagnostic performance of readout-segmented echo-planar diffusion tensor imaging (DTI based on rs-EPI) for breast cancer and to determine the correlation between the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values obtained from DTI based on rs-EPI wi...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Japanese Society for Magnetic Resonance in Medicine
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600032/ https://www.ncbi.nlm.nih.gov/pubmed/27853053 http://dx.doi.org/10.2463/mrms.mp.2016-0037 |
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author | Yamaguchi, Ken Nakazono, Takahiko Egashira, Ryoko Komori, Yoshiaki Nakamura, Jun Noguchi, Tomoyuki Irie, Hiroyuki |
author_facet | Yamaguchi, Ken Nakazono, Takahiko Egashira, Ryoko Komori, Yoshiaki Nakamura, Jun Noguchi, Tomoyuki Irie, Hiroyuki |
author_sort | Yamaguchi, Ken |
collection | PubMed |
description | PURPOSE: To assess the diagnostic performance of readout-segmented echo-planar diffusion tensor imaging (DTI based on rs-EPI) for breast cancer and to determine the correlation between the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values obtained from DTI based on rs-EPI with prognostic markers of invasive breast cancer. MATERIALS AND METHODS: This retrospective study examined 80 pathologically proven breast lesions (22 benign and 58 malignant lesions) of 80 patients who underwent both diffusion-weighted imaging based on single-shot echo-planar imaging (DWI based on ss-EPI) and DTI based on rs-EPI with b-values of 0 and 1000. We identified and compared the diagnostic performances of the DWI based on ss-EPI and the DTI based on rs-EPI using ADCs by conducting a receiver-operating-characteristics (ROC) analysis. We determined the correlations between the ADCs and the prognostic markers and those of the FA values and the same markers. RESULTS: The median ADCs of the benign and malignant lesions based on the ss-EPI were 1.57 and 1.2 × 10(−3) mm(2)/sec, and those based on the rs-EPI were 1.53 and 1.09 × 10(−3) mm(2)/sec, respectively. The area under the curve on the ROC analysis based on rs-EPI (0.924) was greater than that based on ss-EPI (0.897). There were no significant correlations between the ADCs and the prognostic markers, but there were significant correlations between the FA values and the estrogen receptor status, a proliferative marker, the nuclear grade and the intrinsic subtype. CONCLUSION: For breast cancer, DTI based on rs-EPI had superior diagnostic performance compared to DWI based on ss-EPI. Compared with the ADCs, the FA values were more closely correlated with prognostic markers of invasive breast cancer. |
format | Online Article Text |
id | pubmed-5600032 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Japanese Society for Magnetic Resonance in Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-56000322017-10-23 Diagnostic Performance of Diffusion Tensor Imaging with Readout-segmented Echo-planar Imaging for Invasive Breast Cancer: Correlation of ADC and FA with Pathological Prognostic Markers Yamaguchi, Ken Nakazono, Takahiko Egashira, Ryoko Komori, Yoshiaki Nakamura, Jun Noguchi, Tomoyuki Irie, Hiroyuki Magn Reson Med Sci Major Paper PURPOSE: To assess the diagnostic performance of readout-segmented echo-planar diffusion tensor imaging (DTI based on rs-EPI) for breast cancer and to determine the correlation between the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values obtained from DTI based on rs-EPI with prognostic markers of invasive breast cancer. MATERIALS AND METHODS: This retrospective study examined 80 pathologically proven breast lesions (22 benign and 58 malignant lesions) of 80 patients who underwent both diffusion-weighted imaging based on single-shot echo-planar imaging (DWI based on ss-EPI) and DTI based on rs-EPI with b-values of 0 and 1000. We identified and compared the diagnostic performances of the DWI based on ss-EPI and the DTI based on rs-EPI using ADCs by conducting a receiver-operating-characteristics (ROC) analysis. We determined the correlations between the ADCs and the prognostic markers and those of the FA values and the same markers. RESULTS: The median ADCs of the benign and malignant lesions based on the ss-EPI were 1.57 and 1.2 × 10(−3) mm(2)/sec, and those based on the rs-EPI were 1.53 and 1.09 × 10(−3) mm(2)/sec, respectively. The area under the curve on the ROC analysis based on rs-EPI (0.924) was greater than that based on ss-EPI (0.897). There were no significant correlations between the ADCs and the prognostic markers, but there were significant correlations between the FA values and the estrogen receptor status, a proliferative marker, the nuclear grade and the intrinsic subtype. CONCLUSION: For breast cancer, DTI based on rs-EPI had superior diagnostic performance compared to DWI based on ss-EPI. Compared with the ADCs, the FA values were more closely correlated with prognostic markers of invasive breast cancer. Japanese Society for Magnetic Resonance in Medicine 2016-11-16 /pmc/articles/PMC5600032/ /pubmed/27853053 http://dx.doi.org/10.2463/mrms.mp.2016-0037 Text en © 2016 Japanese Society for Magnetic Resonance in Medicine This is an open-access article. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/ |
spellingShingle | Major Paper Yamaguchi, Ken Nakazono, Takahiko Egashira, Ryoko Komori, Yoshiaki Nakamura, Jun Noguchi, Tomoyuki Irie, Hiroyuki Diagnostic Performance of Diffusion Tensor Imaging with Readout-segmented Echo-planar Imaging for Invasive Breast Cancer: Correlation of ADC and FA with Pathological Prognostic Markers |
title | Diagnostic Performance of Diffusion Tensor Imaging with Readout-segmented Echo-planar Imaging for Invasive Breast Cancer: Correlation of ADC and FA with Pathological Prognostic Markers |
title_full | Diagnostic Performance of Diffusion Tensor Imaging with Readout-segmented Echo-planar Imaging for Invasive Breast Cancer: Correlation of ADC and FA with Pathological Prognostic Markers |
title_fullStr | Diagnostic Performance of Diffusion Tensor Imaging with Readout-segmented Echo-planar Imaging for Invasive Breast Cancer: Correlation of ADC and FA with Pathological Prognostic Markers |
title_full_unstemmed | Diagnostic Performance of Diffusion Tensor Imaging with Readout-segmented Echo-planar Imaging for Invasive Breast Cancer: Correlation of ADC and FA with Pathological Prognostic Markers |
title_short | Diagnostic Performance of Diffusion Tensor Imaging with Readout-segmented Echo-planar Imaging for Invasive Breast Cancer: Correlation of ADC and FA with Pathological Prognostic Markers |
title_sort | diagnostic performance of diffusion tensor imaging with readout-segmented echo-planar imaging for invasive breast cancer: correlation of adc and fa with pathological prognostic markers |
topic | Major Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600032/ https://www.ncbi.nlm.nih.gov/pubmed/27853053 http://dx.doi.org/10.2463/mrms.mp.2016-0037 |
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