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Arterial Transit Time-corrected Renal Blood Flow Measurement with Pulsed Continuous Arterial Spin Labeling MR Imaging
PURPOSE: The importance of arterial transit time (ATT) correction for arterial spin labeling MRI has been well debated in neuroimaging, but it has not been well evaluated in renal imaging. The purpose of this study was to evaluate the feasibility of pulsed continuous arterial spin labeling (pcASL) M...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Japanese Society for Magnetic Resonance in Medicine
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600042/ https://www.ncbi.nlm.nih.gov/pubmed/27170422 http://dx.doi.org/10.2463/mrms.mp.2015-0117 |
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author | Shimizu, Kazuhiro Kosaka, Nobuyuki Fujiwara, Yasuhiro Matsuda, Tsuyoshi Yamamoto, Tatsuya Tsuchida, Tatsuro Tsuchiyama, Katsuki Oyama, Nobuyuki Kimura, Hirohiko |
author_facet | Shimizu, Kazuhiro Kosaka, Nobuyuki Fujiwara, Yasuhiro Matsuda, Tsuyoshi Yamamoto, Tatsuya Tsuchida, Tatsuro Tsuchiyama, Katsuki Oyama, Nobuyuki Kimura, Hirohiko |
author_sort | Shimizu, Kazuhiro |
collection | PubMed |
description | PURPOSE: The importance of arterial transit time (ATT) correction for arterial spin labeling MRI has been well debated in neuroimaging, but it has not been well evaluated in renal imaging. The purpose of this study was to evaluate the feasibility of pulsed continuous arterial spin labeling (pcASL) MRI with multiple post-labeling delay (PLD) acquisition for measuring ATT-corrected renal blood flow (ATC-RBF). MATERIALS AND METHODS: A total of 14 volunteers were categorized into younger (n = 8; mean age, 27.0 years) and older groups (n = 6; 64.8 years). Images of pcASL were obtained at three different PLDs (0.5, 1.0, and 1.5 s), and ATC-RBF and ATT were calculated using a single-compartment model. To validate ATC-RBF, a comparative study of effective renal plasma flow (ERPF) measured by (99m)Tc-MAG3 scintigraphy was performed. ATC-RBF was corrected by kidney volume (ATC-cRBF) for comparison with ERPF. RESULTS: The younger group showed significantly higher ATC-RBF (157.68 ± 38.37 mL/min/100 g) and shorter ATT (961.33 ± 260.87 ms) than the older group (117.42 ± 24.03 mL/min/100 g and 1227.94 ± 226.51 ms, respectively; P < 0.05). A significant correlation was evident between ATC-cRBF and ERPF (P < 0.05, r = 0.47). With suboptimal single PLD (1.5 s) settings, there was no significant correlation between ERPF and kidney volume-corrected RBF calculated from single PLD data. CONCLUSION: Calculation of ATT and ATC-RBF by pcASL with multiple PLD was feasible in healthy volunteers, and differences in ATT and ATC-RBF were seen between the younger and older groups. Although ATT correction by multiple PLD acquisitions may not always be necessary for RBF quantification in the healthy subjects, the effect of ATT should be taken into account in renal ASL–MRI as debated in brain imaging. |
format | Online Article Text |
id | pubmed-5600042 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Japanese Society for Magnetic Resonance in Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-56000422017-10-23 Arterial Transit Time-corrected Renal Blood Flow Measurement with Pulsed Continuous Arterial Spin Labeling MR Imaging Shimizu, Kazuhiro Kosaka, Nobuyuki Fujiwara, Yasuhiro Matsuda, Tsuyoshi Yamamoto, Tatsuya Tsuchida, Tatsuro Tsuchiyama, Katsuki Oyama, Nobuyuki Kimura, Hirohiko Magn Reson Med Sci Major Paper PURPOSE: The importance of arterial transit time (ATT) correction for arterial spin labeling MRI has been well debated in neuroimaging, but it has not been well evaluated in renal imaging. The purpose of this study was to evaluate the feasibility of pulsed continuous arterial spin labeling (pcASL) MRI with multiple post-labeling delay (PLD) acquisition for measuring ATT-corrected renal blood flow (ATC-RBF). MATERIALS AND METHODS: A total of 14 volunteers were categorized into younger (n = 8; mean age, 27.0 years) and older groups (n = 6; 64.8 years). Images of pcASL were obtained at three different PLDs (0.5, 1.0, and 1.5 s), and ATC-RBF and ATT were calculated using a single-compartment model. To validate ATC-RBF, a comparative study of effective renal plasma flow (ERPF) measured by (99m)Tc-MAG3 scintigraphy was performed. ATC-RBF was corrected by kidney volume (ATC-cRBF) for comparison with ERPF. RESULTS: The younger group showed significantly higher ATC-RBF (157.68 ± 38.37 mL/min/100 g) and shorter ATT (961.33 ± 260.87 ms) than the older group (117.42 ± 24.03 mL/min/100 g and 1227.94 ± 226.51 ms, respectively; P < 0.05). A significant correlation was evident between ATC-cRBF and ERPF (P < 0.05, r = 0.47). With suboptimal single PLD (1.5 s) settings, there was no significant correlation between ERPF and kidney volume-corrected RBF calculated from single PLD data. CONCLUSION: Calculation of ATT and ATC-RBF by pcASL with multiple PLD was feasible in healthy volunteers, and differences in ATT and ATC-RBF were seen between the younger and older groups. Although ATT correction by multiple PLD acquisitions may not always be necessary for RBF quantification in the healthy subjects, the effect of ATT should be taken into account in renal ASL–MRI as debated in brain imaging. Japanese Society for Magnetic Resonance in Medicine 2016-05-09 /pmc/articles/PMC5600042/ /pubmed/27170422 http://dx.doi.org/10.2463/mrms.mp.2015-0117 Text en © 2016 Japanese Society for Magnetic Resonance in Medicine http://creativecommons.org/licenses/by/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives International License. |
spellingShingle | Major Paper Shimizu, Kazuhiro Kosaka, Nobuyuki Fujiwara, Yasuhiro Matsuda, Tsuyoshi Yamamoto, Tatsuya Tsuchida, Tatsuro Tsuchiyama, Katsuki Oyama, Nobuyuki Kimura, Hirohiko Arterial Transit Time-corrected Renal Blood Flow Measurement with Pulsed Continuous Arterial Spin Labeling MR Imaging |
title | Arterial Transit Time-corrected Renal Blood Flow Measurement with Pulsed Continuous Arterial Spin Labeling MR Imaging |
title_full | Arterial Transit Time-corrected Renal Blood Flow Measurement with Pulsed Continuous Arterial Spin Labeling MR Imaging |
title_fullStr | Arterial Transit Time-corrected Renal Blood Flow Measurement with Pulsed Continuous Arterial Spin Labeling MR Imaging |
title_full_unstemmed | Arterial Transit Time-corrected Renal Blood Flow Measurement with Pulsed Continuous Arterial Spin Labeling MR Imaging |
title_short | Arterial Transit Time-corrected Renal Blood Flow Measurement with Pulsed Continuous Arterial Spin Labeling MR Imaging |
title_sort | arterial transit time-corrected renal blood flow measurement with pulsed continuous arterial spin labeling mr imaging |
topic | Major Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600042/ https://www.ncbi.nlm.nih.gov/pubmed/27170422 http://dx.doi.org/10.2463/mrms.mp.2015-0117 |
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