Profiling of Microbial Colonies for High-Throughput Engineering of Multistep Enzymatic Reactions via Optically Guided Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry

[Image: see text] Matrix-assisted laser desorption/ionization time-of-flight (MALDI-ToF) mass spectrometry (MS) imaging has been used for rapid phenotyping of enzymatic activities, but is mainly limited to single-step conversions. Herein we report a label-free method for high-throughput engineering...

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Detalles Bibliográficos
Autores principales: Si, Tong, Li, Bin, Comi, Troy J., Wu, Yuwei, Hu, Pingfan, Wu, Yuying, Min, Yuhao, Mitchell, Douglas A., Zhao, Huimin, Sweedler, Jonathan V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600186/
https://www.ncbi.nlm.nih.gov/pubmed/28792758
http://dx.doi.org/10.1021/jacs.7b04641

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