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let-7b and let-7c microRNAs promote histone H2B ubiquitylation and inhibit cell migration by targeting multiple components of the H2B deubiquitylation machinery

Monoubiquitylation of histone H2B (H2Bub1) is catalyzed mainly by the RNF20/RNF40 complex and erased by multiple deubiquitylating enzymes (DUBs). H2Bub1 influences many aspects of chromatin function, including transcription regulation and DNA repair. Cancer cells often display reduced levels of H2Bu...

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Detalles Bibliográficos
Autores principales:	Spolverini, Ambra, Fuchs, Gilad, Bublik, Débora Rosa, Oren, Moshe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600258/ https://www.ncbi.nlm.nih.gov/pubmed/28604753 http://dx.doi.org/10.1038/onc.2017.187

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