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Obesity is not associated with recurrent venous thromboembolism in elderly patients: Results from the prospective SWITCO65+ cohort study

BACKGROUND: Whether obesity is associated with recurrent venous thromboembolism (VTE) in elderly patients is unknown. OBJECTIVES: To examine the association between two obesity measures, the body mass index (BMI) and the waist circumference (WC), and recurrent VTE in elderly patients. PATIENTS/METHO...

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Autores principales: Mueller, Carolin, Limacher, Andreas, Méan, Marie, Rodondi, Nicolas, Aujesky, Drahomir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600372/
https://www.ncbi.nlm.nih.gov/pubmed/28915260
http://dx.doi.org/10.1371/journal.pone.0184868
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author Mueller, Carolin
Limacher, Andreas
Méan, Marie
Rodondi, Nicolas
Aujesky, Drahomir
author_facet Mueller, Carolin
Limacher, Andreas
Méan, Marie
Rodondi, Nicolas
Aujesky, Drahomir
author_sort Mueller, Carolin
collection PubMed
description BACKGROUND: Whether obesity is associated with recurrent venous thromboembolism (VTE) in elderly patients is unknown. OBJECTIVES: To examine the association between two obesity measures, the body mass index (BMI) and the waist circumference (WC), and recurrent VTE in elderly patients. PATIENTS/METHODS: We studied 986 patients aged ≥65 years with an acute VTE from a prospective multicenter cohort study (09/2009-12/2013). The BMI was determined and categorized as <25, 25 to <30, or ≥30 kg/m(2). The WC was categorized as <80 cm in women (w)/<94 cm in men (m), 80 to <88 cm (w)/94 to <102 cm (m), or ≥88 cm (w)/≥102 cm (m). We examined the association between the BMI and the WC and the time to a first symptomatic recurrent VTE using competing risk regression, adjusting for known risk factors of VTE recurrence and periods of anticoagulation. RESULTS: The mean follow-up was 28 months. The 3-year cumulative incidence of recurrent VTE did not vary by BMI and was 17.6% for a BMI <25 kg/m(2), 11.5% for a BMI 25 to <30 kg/m(2), and 16.9% for a BMI ≥30 kg/m(2) (P = 0.09). The 3-year cumulative incidence of recurrent VTE did not vary by WC. After adjustment, neither the BMI (sub-hazard ratio [SHR] 1.02, 95% confidence interval [CI 0.98–1.05]) nor the WC (SHR 1.01, 95% CI 0.99–1.02) was associated with recurrent VTE. CONCLUSIONS: Measures of body weight were not associated with recurrent VTE in our cohort. Obesity does not appear to be a predictor of recurrent VTE in the elderly.
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spelling pubmed-56003722017-09-22 Obesity is not associated with recurrent venous thromboembolism in elderly patients: Results from the prospective SWITCO65+ cohort study Mueller, Carolin Limacher, Andreas Méan, Marie Rodondi, Nicolas Aujesky, Drahomir PLoS One Research Article BACKGROUND: Whether obesity is associated with recurrent venous thromboembolism (VTE) in elderly patients is unknown. OBJECTIVES: To examine the association between two obesity measures, the body mass index (BMI) and the waist circumference (WC), and recurrent VTE in elderly patients. PATIENTS/METHODS: We studied 986 patients aged ≥65 years with an acute VTE from a prospective multicenter cohort study (09/2009-12/2013). The BMI was determined and categorized as <25, 25 to <30, or ≥30 kg/m(2). The WC was categorized as <80 cm in women (w)/<94 cm in men (m), 80 to <88 cm (w)/94 to <102 cm (m), or ≥88 cm (w)/≥102 cm (m). We examined the association between the BMI and the WC and the time to a first symptomatic recurrent VTE using competing risk regression, adjusting for known risk factors of VTE recurrence and periods of anticoagulation. RESULTS: The mean follow-up was 28 months. The 3-year cumulative incidence of recurrent VTE did not vary by BMI and was 17.6% for a BMI <25 kg/m(2), 11.5% for a BMI 25 to <30 kg/m(2), and 16.9% for a BMI ≥30 kg/m(2) (P = 0.09). The 3-year cumulative incidence of recurrent VTE did not vary by WC. After adjustment, neither the BMI (sub-hazard ratio [SHR] 1.02, 95% confidence interval [CI 0.98–1.05]) nor the WC (SHR 1.01, 95% CI 0.99–1.02) was associated with recurrent VTE. CONCLUSIONS: Measures of body weight were not associated with recurrent VTE in our cohort. Obesity does not appear to be a predictor of recurrent VTE in the elderly. Public Library of Science 2017-09-15 /pmc/articles/PMC5600372/ /pubmed/28915260 http://dx.doi.org/10.1371/journal.pone.0184868 Text en © 2017 Mueller et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Mueller, Carolin
Limacher, Andreas
Méan, Marie
Rodondi, Nicolas
Aujesky, Drahomir
Obesity is not associated with recurrent venous thromboembolism in elderly patients: Results from the prospective SWITCO65+ cohort study
title Obesity is not associated with recurrent venous thromboembolism in elderly patients: Results from the prospective SWITCO65+ cohort study
title_full Obesity is not associated with recurrent venous thromboembolism in elderly patients: Results from the prospective SWITCO65+ cohort study
title_fullStr Obesity is not associated with recurrent venous thromboembolism in elderly patients: Results from the prospective SWITCO65+ cohort study
title_full_unstemmed Obesity is not associated with recurrent venous thromboembolism in elderly patients: Results from the prospective SWITCO65+ cohort study
title_short Obesity is not associated with recurrent venous thromboembolism in elderly patients: Results from the prospective SWITCO65+ cohort study
title_sort obesity is not associated with recurrent venous thromboembolism in elderly patients: results from the prospective switco65+ cohort study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600372/
https://www.ncbi.nlm.nih.gov/pubmed/28915260
http://dx.doi.org/10.1371/journal.pone.0184868
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