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Obesity is not associated with recurrent venous thromboembolism in elderly patients: Results from the prospective SWITCO65+ cohort study
BACKGROUND: Whether obesity is associated with recurrent venous thromboembolism (VTE) in elderly patients is unknown. OBJECTIVES: To examine the association between two obesity measures, the body mass index (BMI) and the waist circumference (WC), and recurrent VTE in elderly patients. PATIENTS/METHO...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600372/ https://www.ncbi.nlm.nih.gov/pubmed/28915260 http://dx.doi.org/10.1371/journal.pone.0184868 |
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author | Mueller, Carolin Limacher, Andreas Méan, Marie Rodondi, Nicolas Aujesky, Drahomir |
author_facet | Mueller, Carolin Limacher, Andreas Méan, Marie Rodondi, Nicolas Aujesky, Drahomir |
author_sort | Mueller, Carolin |
collection | PubMed |
description | BACKGROUND: Whether obesity is associated with recurrent venous thromboembolism (VTE) in elderly patients is unknown. OBJECTIVES: To examine the association between two obesity measures, the body mass index (BMI) and the waist circumference (WC), and recurrent VTE in elderly patients. PATIENTS/METHODS: We studied 986 patients aged ≥65 years with an acute VTE from a prospective multicenter cohort study (09/2009-12/2013). The BMI was determined and categorized as <25, 25 to <30, or ≥30 kg/m(2). The WC was categorized as <80 cm in women (w)/<94 cm in men (m), 80 to <88 cm (w)/94 to <102 cm (m), or ≥88 cm (w)/≥102 cm (m). We examined the association between the BMI and the WC and the time to a first symptomatic recurrent VTE using competing risk regression, adjusting for known risk factors of VTE recurrence and periods of anticoagulation. RESULTS: The mean follow-up was 28 months. The 3-year cumulative incidence of recurrent VTE did not vary by BMI and was 17.6% for a BMI <25 kg/m(2), 11.5% for a BMI 25 to <30 kg/m(2), and 16.9% for a BMI ≥30 kg/m(2) (P = 0.09). The 3-year cumulative incidence of recurrent VTE did not vary by WC. After adjustment, neither the BMI (sub-hazard ratio [SHR] 1.02, 95% confidence interval [CI 0.98–1.05]) nor the WC (SHR 1.01, 95% CI 0.99–1.02) was associated with recurrent VTE. CONCLUSIONS: Measures of body weight were not associated with recurrent VTE in our cohort. Obesity does not appear to be a predictor of recurrent VTE in the elderly. |
format | Online Article Text |
id | pubmed-5600372 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-56003722017-09-22 Obesity is not associated with recurrent venous thromboembolism in elderly patients: Results from the prospective SWITCO65+ cohort study Mueller, Carolin Limacher, Andreas Méan, Marie Rodondi, Nicolas Aujesky, Drahomir PLoS One Research Article BACKGROUND: Whether obesity is associated with recurrent venous thromboembolism (VTE) in elderly patients is unknown. OBJECTIVES: To examine the association between two obesity measures, the body mass index (BMI) and the waist circumference (WC), and recurrent VTE in elderly patients. PATIENTS/METHODS: We studied 986 patients aged ≥65 years with an acute VTE from a prospective multicenter cohort study (09/2009-12/2013). The BMI was determined and categorized as <25, 25 to <30, or ≥30 kg/m(2). The WC was categorized as <80 cm in women (w)/<94 cm in men (m), 80 to <88 cm (w)/94 to <102 cm (m), or ≥88 cm (w)/≥102 cm (m). We examined the association between the BMI and the WC and the time to a first symptomatic recurrent VTE using competing risk regression, adjusting for known risk factors of VTE recurrence and periods of anticoagulation. RESULTS: The mean follow-up was 28 months. The 3-year cumulative incidence of recurrent VTE did not vary by BMI and was 17.6% for a BMI <25 kg/m(2), 11.5% for a BMI 25 to <30 kg/m(2), and 16.9% for a BMI ≥30 kg/m(2) (P = 0.09). The 3-year cumulative incidence of recurrent VTE did not vary by WC. After adjustment, neither the BMI (sub-hazard ratio [SHR] 1.02, 95% confidence interval [CI 0.98–1.05]) nor the WC (SHR 1.01, 95% CI 0.99–1.02) was associated with recurrent VTE. CONCLUSIONS: Measures of body weight were not associated with recurrent VTE in our cohort. Obesity does not appear to be a predictor of recurrent VTE in the elderly. Public Library of Science 2017-09-15 /pmc/articles/PMC5600372/ /pubmed/28915260 http://dx.doi.org/10.1371/journal.pone.0184868 Text en © 2017 Mueller et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Mueller, Carolin Limacher, Andreas Méan, Marie Rodondi, Nicolas Aujesky, Drahomir Obesity is not associated with recurrent venous thromboembolism in elderly patients: Results from the prospective SWITCO65+ cohort study |
title | Obesity is not associated with recurrent venous thromboembolism in elderly patients: Results from the prospective SWITCO65+ cohort study |
title_full | Obesity is not associated with recurrent venous thromboembolism in elderly patients: Results from the prospective SWITCO65+ cohort study |
title_fullStr | Obesity is not associated with recurrent venous thromboembolism in elderly patients: Results from the prospective SWITCO65+ cohort study |
title_full_unstemmed | Obesity is not associated with recurrent venous thromboembolism in elderly patients: Results from the prospective SWITCO65+ cohort study |
title_short | Obesity is not associated with recurrent venous thromboembolism in elderly patients: Results from the prospective SWITCO65+ cohort study |
title_sort | obesity is not associated with recurrent venous thromboembolism in elderly patients: results from the prospective switco65+ cohort study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600372/ https://www.ncbi.nlm.nih.gov/pubmed/28915260 http://dx.doi.org/10.1371/journal.pone.0184868 |
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