Outbreaks of epidemic keratoconjunctivitis caused by human adenovirus type 8 in the Tibet Autonomous Region of China in 2016

From April to November 2016, two outbreaks of epidemic keratoconjunctivitis (EKC) occurred successively at primary and middle schools in the Tibet Autonomous Region of China, and a total of 197 clinically diagnosed cases were reported. Real-time PCR analyses confirmed that human adenovirus (HAdV) in...

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Autores principales: Lei, Zhenqiang, Zhu, Zhen, wang, Bai ma ci, mei, Hong, Li, Hong, ga, Dan zeng gong, jie, Guo, chi, Mi ma bu, Zhang, Sheng, Ma, Chaofeng, Xu, Wenbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600394/
https://www.ncbi.nlm.nih.gov/pubmed/28915257
http://dx.doi.org/10.1371/journal.pone.0185048
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author Lei, Zhenqiang
Zhu, Zhen
wang, Bai ma ci
mei, Hong
Li, Hong
ga, Dan zeng gong
jie, Guo
chi, Mi ma bu
Zhang, Sheng
Ma, Chaofeng
Xu, Wenbo
author_facet Lei, Zhenqiang
Zhu, Zhen
wang, Bai ma ci
mei, Hong
Li, Hong
ga, Dan zeng gong
jie, Guo
chi, Mi ma bu
Zhang, Sheng
Ma, Chaofeng
Xu, Wenbo
author_sort Lei, Zhenqiang
collection PubMed
description From April to November 2016, two outbreaks of epidemic keratoconjunctivitis (EKC) occurred successively at primary and middle schools in the Tibet Autonomous Region of China, and a total of 197 clinically diagnosed cases were reported. Real-time PCR analyses confirmed that human adenovirus (HAdV) infection was related to these outbreaks. Further studies involving sequence determination and phylogenetic analysis based on the penton base, hexon, and fiber genes indicated that human adenovirus type 8 (HAdV-8), belonging to species D, was responsible for the outbreaks. This is the first report of a HAdV-8 associated EKC outbreak in mainland of China, and the results of this study are expected to provide support for future research into HAdV-8 in China.
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spelling pubmed-56003942017-09-22 Outbreaks of epidemic keratoconjunctivitis caused by human adenovirus type 8 in the Tibet Autonomous Region of China in 2016 Lei, Zhenqiang Zhu, Zhen wang, Bai ma ci mei, Hong Li, Hong ga, Dan zeng gong jie, Guo chi, Mi ma bu Zhang, Sheng Ma, Chaofeng Xu, Wenbo PLoS One Research Article From April to November 2016, two outbreaks of epidemic keratoconjunctivitis (EKC) occurred successively at primary and middle schools in the Tibet Autonomous Region of China, and a total of 197 clinically diagnosed cases were reported. Real-time PCR analyses confirmed that human adenovirus (HAdV) infection was related to these outbreaks. Further studies involving sequence determination and phylogenetic analysis based on the penton base, hexon, and fiber genes indicated that human adenovirus type 8 (HAdV-8), belonging to species D, was responsible for the outbreaks. This is the first report of a HAdV-8 associated EKC outbreak in mainland of China, and the results of this study are expected to provide support for future research into HAdV-8 in China. Public Library of Science 2017-09-15 /pmc/articles/PMC5600394/ /pubmed/28915257 http://dx.doi.org/10.1371/journal.pone.0185048 Text en © 2017 Lei et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Lei, Zhenqiang
Zhu, Zhen
wang, Bai ma ci
mei, Hong
Li, Hong
ga, Dan zeng gong
jie, Guo
chi, Mi ma bu
Zhang, Sheng
Ma, Chaofeng
Xu, Wenbo
Outbreaks of epidemic keratoconjunctivitis caused by human adenovirus type 8 in the Tibet Autonomous Region of China in 2016
title Outbreaks of epidemic keratoconjunctivitis caused by human adenovirus type 8 in the Tibet Autonomous Region of China in 2016
title_full Outbreaks of epidemic keratoconjunctivitis caused by human adenovirus type 8 in the Tibet Autonomous Region of China in 2016
title_fullStr Outbreaks of epidemic keratoconjunctivitis caused by human adenovirus type 8 in the Tibet Autonomous Region of China in 2016
title_full_unstemmed Outbreaks of epidemic keratoconjunctivitis caused by human adenovirus type 8 in the Tibet Autonomous Region of China in 2016
title_short Outbreaks of epidemic keratoconjunctivitis caused by human adenovirus type 8 in the Tibet Autonomous Region of China in 2016
title_sort outbreaks of epidemic keratoconjunctivitis caused by human adenovirus type 8 in the tibet autonomous region of china in 2016
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600394/
https://www.ncbi.nlm.nih.gov/pubmed/28915257
http://dx.doi.org/10.1371/journal.pone.0185048
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