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Deleterious effect of Usutu virus on human neural cells
In the last decade, the number of emerging Flaviviruses described worldwide has increased considerably. Among them Zika virus (ZIKV) and Usutu virus (USUV) are African mosquito-borne viruses that recently emerged. Recently, ZIKV has been intensely studied due to major outbreaks associated with neona...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600396/ https://www.ncbi.nlm.nih.gov/pubmed/28873445 http://dx.doi.org/10.1371/journal.pntd.0005913 |
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author | Salinas, Sara Constant, Orianne Desmetz, Caroline Barthelemy, Jonathan Lemaitre, Jean-Marc Milhavet, Ollivier Nagot, Nicolas Foulongne, Vincent Perrin, Florence E. Saiz, Juan-Carlos Lecollinet, Sylvie Van de Perre, Philippe Simonin, Yannick |
author_facet | Salinas, Sara Constant, Orianne Desmetz, Caroline Barthelemy, Jonathan Lemaitre, Jean-Marc Milhavet, Ollivier Nagot, Nicolas Foulongne, Vincent Perrin, Florence E. Saiz, Juan-Carlos Lecollinet, Sylvie Van de Perre, Philippe Simonin, Yannick |
author_sort | Salinas, Sara |
collection | PubMed |
description | In the last decade, the number of emerging Flaviviruses described worldwide has increased considerably. Among them Zika virus (ZIKV) and Usutu virus (USUV) are African mosquito-borne viruses that recently emerged. Recently, ZIKV has been intensely studied due to major outbreaks associated with neonatal death and birth defects, as well as neurological symptoms. USUV pathogenesis remains largely unexplored, despite significant human and veterinary associated disorders. Circulation of USUV in Africa was documented more than 50 years ago, and it emerged in Europe two decades ago, causing massive bird mortality. More recently, USUV has been described to be associated with neurological disorders in humans such as encephalitis and meningoencephalitis, highlighting USUV as a potential health threat. The aim of this study was to evaluate the ability of USUV to infect neuronal cells. Our results indicate that USUV efficiently infects neurons, astrocytes, microglia and IPSc-derived human neuronal stem cells. When compared to ZIKV, USUV led to a higher infection rate, viral production, as well as stronger cell death and anti-viral response. Our results highlight the need to better characterize the physiopathology related to USUV infection in order to anticipate the potential threat of USUV emergence. |
format | Online Article Text |
id | pubmed-5600396 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-56003962017-09-22 Deleterious effect of Usutu virus on human neural cells Salinas, Sara Constant, Orianne Desmetz, Caroline Barthelemy, Jonathan Lemaitre, Jean-Marc Milhavet, Ollivier Nagot, Nicolas Foulongne, Vincent Perrin, Florence E. Saiz, Juan-Carlos Lecollinet, Sylvie Van de Perre, Philippe Simonin, Yannick PLoS Negl Trop Dis Research Article In the last decade, the number of emerging Flaviviruses described worldwide has increased considerably. Among them Zika virus (ZIKV) and Usutu virus (USUV) are African mosquito-borne viruses that recently emerged. Recently, ZIKV has been intensely studied due to major outbreaks associated with neonatal death and birth defects, as well as neurological symptoms. USUV pathogenesis remains largely unexplored, despite significant human and veterinary associated disorders. Circulation of USUV in Africa was documented more than 50 years ago, and it emerged in Europe two decades ago, causing massive bird mortality. More recently, USUV has been described to be associated with neurological disorders in humans such as encephalitis and meningoencephalitis, highlighting USUV as a potential health threat. The aim of this study was to evaluate the ability of USUV to infect neuronal cells. Our results indicate that USUV efficiently infects neurons, astrocytes, microglia and IPSc-derived human neuronal stem cells. When compared to ZIKV, USUV led to a higher infection rate, viral production, as well as stronger cell death and anti-viral response. Our results highlight the need to better characterize the physiopathology related to USUV infection in order to anticipate the potential threat of USUV emergence. Public Library of Science 2017-09-05 /pmc/articles/PMC5600396/ /pubmed/28873445 http://dx.doi.org/10.1371/journal.pntd.0005913 Text en © 2017 Salinas et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Salinas, Sara Constant, Orianne Desmetz, Caroline Barthelemy, Jonathan Lemaitre, Jean-Marc Milhavet, Ollivier Nagot, Nicolas Foulongne, Vincent Perrin, Florence E. Saiz, Juan-Carlos Lecollinet, Sylvie Van de Perre, Philippe Simonin, Yannick Deleterious effect of Usutu virus on human neural cells |
title | Deleterious effect of Usutu virus on human neural cells |
title_full | Deleterious effect of Usutu virus on human neural cells |
title_fullStr | Deleterious effect of Usutu virus on human neural cells |
title_full_unstemmed | Deleterious effect of Usutu virus on human neural cells |
title_short | Deleterious effect of Usutu virus on human neural cells |
title_sort | deleterious effect of usutu virus on human neural cells |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600396/ https://www.ncbi.nlm.nih.gov/pubmed/28873445 http://dx.doi.org/10.1371/journal.pntd.0005913 |
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