Receptor and post-receptor abnormalities contribute to insulin resistance in myotonic dystrophy type 1 and type 2 skeletal muscle

Myotonic dystrophy type 1 (DM1) and type 2 (DM2) are autosomal dominant multisystemic disorders caused by expansion of microsatellite repeats. In both forms, the mutant transcripts accumulate in nuclear foci altering the function of alternative splicing regulators which are necessary for the physiol...

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Detalles Bibliográficos
Autores principales: Renna, Laura Valentina, Bosè, Francesca, Iachettini, Sara, Fossati, Barbara, Saraceno, Lorenzo, Milani, Valentina, Colombo, Roberto, Meola, Giovanni, Cardani, Rosanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600405/
https://www.ncbi.nlm.nih.gov/pubmed/28915272
http://dx.doi.org/10.1371/journal.pone.0184987

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