Enhancement of C2C12 myoblast proliferation and differentiation by GASP-2, a myostatin inhibitor

BACKGROUND: GASP-2 is a secreted multi-domain glycoprotein known as a specific inhibitor of myostatin and GDF-11. Here we investigate the role of GASP-2 on myogenesis and the effect of its glycosylation on its activity. METHODS: GASP-2 overexpression or knockdown by shRNAs were carried out on C2C12...

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Detalles Bibliográficos
Autores principales: Pèrié, Luce, Parenté, Alexis, Brun, Caroline, Magnol, Laetitia, Pélissier, Patrick, Blanquet, Véronique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600423/
https://www.ncbi.nlm.nih.gov/pubmed/28955860
http://dx.doi.org/10.1016/j.bbrep.2016.03.001

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