Abnormal gait, reduced locomotor activity and impaired motor coordination in Dgcr2-deficient mice

It has been suggested that the DGCR2 gene plays a role in the pathogenesis of 22q11.2 deletion syndrome. To analyze its function, we used our Dgcr2-knock-out/EGFP-knock-in mice (Dgcr2-KO mice). At 20-26 weeks of age, approximately 20% of Dgcr2-KO mice showed gait abnormalities with trembling and dif...

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Detalles Bibliográficos
Autores principales: Mugikura, Shin-ichiro, Katoh, Akira, Watanabe, Satoshi, Kimura, Minoru, Kajiwara, Kagemasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600435/
https://www.ncbi.nlm.nih.gov/pubmed/28955813
http://dx.doi.org/10.1016/j.bbrep.2015.11.015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600435/
https://www.ncbi.nlm.nih.gov/pubmed/28955813
http://dx.doi.org/10.1016/j.bbrep.2015.11.015

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