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A bouquet of DNA structures: Emerging diversity

Structural polymorphism of DNA has constantly been evolving from the time of illustration of the double helical model of DNA by Watson and Crick. A variety of non-canonical DNA structures have constantly been documented across the globe. DNA attracted worldwide attention as a carrier of genetic info...

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Autores principales: Kaushik, Mahima, Kaushik, Shikha, Roy, Kapil, Singh, Anju, Mahendru, Swati, Kumar, Mohan, Chaudhary, Swati, Ahmed, Saami, Kukreti, Shrikant
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600441/
https://www.ncbi.nlm.nih.gov/pubmed/28955846
http://dx.doi.org/10.1016/j.bbrep.2016.01.013
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author Kaushik, Mahima
Kaushik, Shikha
Roy, Kapil
Singh, Anju
Mahendru, Swati
Kumar, Mohan
Chaudhary, Swati
Ahmed, Saami
Kukreti, Shrikant
author_facet Kaushik, Mahima
Kaushik, Shikha
Roy, Kapil
Singh, Anju
Mahendru, Swati
Kumar, Mohan
Chaudhary, Swati
Ahmed, Saami
Kukreti, Shrikant
author_sort Kaushik, Mahima
collection PubMed
description Structural polymorphism of DNA has constantly been evolving from the time of illustration of the double helical model of DNA by Watson and Crick. A variety of non-canonical DNA structures have constantly been documented across the globe. DNA attracted worldwide attention as a carrier of genetic information. In addition to the classical Watson–Crick duplex, DNA can actually adopt diverse structures during its active participation in cellular processes like replication, transcription, recombination and repair. Structures like hairpin, cruciform, triplex, G-triplex, quadruplex, i-motif and other alternative non-canonical DNA structures have been studied at length and have also shown their in vivo occurrence. This review mainly focuses on non-canonical structures adopted by DNA oligonucleotides which have certain prerequisites for their formation in terms of sequence, its length, number and orientation of strands along with varied solution conditions. This conformational polymorphism of DNA might be the basis of different functional properties of a specific set of DNA sequences, further giving some insights for various extremely complicated biological phenomena. Many of these structures have already shown their linkages with diseases like cancer and genetic disorders, hence making them an extremely striking target for structure-specific drug designing and therapeutic applications.
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spelling pubmed-56004412017-09-27 A bouquet of DNA structures: Emerging diversity Kaushik, Mahima Kaushik, Shikha Roy, Kapil Singh, Anju Mahendru, Swati Kumar, Mohan Chaudhary, Swati Ahmed, Saami Kukreti, Shrikant Biochem Biophys Rep Review Article Structural polymorphism of DNA has constantly been evolving from the time of illustration of the double helical model of DNA by Watson and Crick. A variety of non-canonical DNA structures have constantly been documented across the globe. DNA attracted worldwide attention as a carrier of genetic information. In addition to the classical Watson–Crick duplex, DNA can actually adopt diverse structures during its active participation in cellular processes like replication, transcription, recombination and repair. Structures like hairpin, cruciform, triplex, G-triplex, quadruplex, i-motif and other alternative non-canonical DNA structures have been studied at length and have also shown their in vivo occurrence. This review mainly focuses on non-canonical structures adopted by DNA oligonucleotides which have certain prerequisites for their formation in terms of sequence, its length, number and orientation of strands along with varied solution conditions. This conformational polymorphism of DNA might be the basis of different functional properties of a specific set of DNA sequences, further giving some insights for various extremely complicated biological phenomena. Many of these structures have already shown their linkages with diseases like cancer and genetic disorders, hence making them an extremely striking target for structure-specific drug designing and therapeutic applications. Elsevier 2016-01-28 /pmc/articles/PMC5600441/ /pubmed/28955846 http://dx.doi.org/10.1016/j.bbrep.2016.01.013 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Kaushik, Mahima
Kaushik, Shikha
Roy, Kapil
Singh, Anju
Mahendru, Swati
Kumar, Mohan
Chaudhary, Swati
Ahmed, Saami
Kukreti, Shrikant
A bouquet of DNA structures: Emerging diversity
title A bouquet of DNA structures: Emerging diversity
title_full A bouquet of DNA structures: Emerging diversity
title_fullStr A bouquet of DNA structures: Emerging diversity
title_full_unstemmed A bouquet of DNA structures: Emerging diversity
title_short A bouquet of DNA structures: Emerging diversity
title_sort bouquet of dna structures: emerging diversity
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600441/
https://www.ncbi.nlm.nih.gov/pubmed/28955846
http://dx.doi.org/10.1016/j.bbrep.2016.01.013
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