Lysosomal membrane permeabilization is involved in oxidative stress-induced apoptotic cell death in LAMP2-deficient iPSCs-derived cerebral cortical neurons

Patients with Danon disease may suffer from severe cardiomyopathy, skeletal muscle dysfunction as well as varying degrees of mental retardation, in which the primary deficiency of lysosomal membrane-associated protein-2 (LAMP2) is considerably associated. Owing to the scarcity of human neurons, the...

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Detalles Bibliográficos
Autores principales: Law, Cheuk-Yiu, Siu, Chung-Wah, Fan, Katherine, Lai, Wing-Hon, Au, Ka-Wing, Lau, Yee-Man, Wong, Lai-Yung, Ho, Jenny C.Y., Lee, Yee-ki, Tse, Hung-Fat, Ng, Kwong-Man
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600451/
https://www.ncbi.nlm.nih.gov/pubmed/28955840
http://dx.doi.org/10.1016/j.bbrep.2016.01.010

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