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Distinct Roles of Catalytic Cysteine and Histidine in the Protease and Ligase Mechanisms of Human Legumain As Revealed by DFT-Based QM/MM Simulations
[Image: see text] The cysteine protease enzyme legumain hydrolyzes peptide bonds with high specificity after asparagine and under more acidic conditions after aspartic acid [ E. N. BakerJ. Mol. Biol.1980, 141, 441−4847003158; E. N. Baker; J. Mol. Biol.1977, 111, 207–210859183; J. Drenth; Biochemistr...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American
Chemical Society
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600538/ https://www.ncbi.nlm.nih.gov/pubmed/28932620 http://dx.doi.org/10.1021/acscatal.7b01505 |