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Distinct Roles of Catalytic Cysteine and Histidine in the Protease and Ligase Mechanisms of Human Legumain As Revealed by DFT-Based QM/MM Simulations

[Image: see text] The cysteine protease enzyme legumain hydrolyzes peptide bonds with high specificity after asparagine and under more acidic conditions after aspartic acid [ E. N. BakerJ. Mol. Biol.1980, 141, 441−4847003158; E. N. Baker; J. Mol. Biol.1977, 111, 207–210859183; J. Drenth; Biochemistr...

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Detalles Bibliográficos
Autores principales:	Elsässer, Brigitta, Zauner, Florian B., Messner, Johann, Soh, Wai Tuck, Dall, Elfriede, Brandstetter, Hans
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2017
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600538/ https://www.ncbi.nlm.nih.gov/pubmed/28932620 http://dx.doi.org/10.1021/acscatal.7b01505

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