Familial Myelodysplastic/Acute Leukemia Syndromes—Myeloid Neoplasms with Germline Predisposition

Although most cases of myeloid neoplasms are sporadic, a small subset has been associated with germline mutations. The 2016 revision of the World Health Organization classification included these cases in a myeloid neoplasm group with a predisposing germline mutational background. These patients mus...

Descripción completa

Detalles Bibliográficos
Autores principales: Baptista, Renata Lyrio Rafael, dos Santos, Anna Cláudia Evangelista, Gutiyama, Luciana Mayumi, Solza, Cristiana, Zalcberg, Ilana Renault
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600909/
https://www.ncbi.nlm.nih.gov/pubmed/28955657
http://dx.doi.org/10.3389/fonc.2017.00206
_version_ 1783264290676932608
author Baptista, Renata Lyrio Rafael
dos Santos, Anna Cláudia Evangelista
Gutiyama, Luciana Mayumi
Solza, Cristiana
Zalcberg, Ilana Renault
author_facet Baptista, Renata Lyrio Rafael
dos Santos, Anna Cláudia Evangelista
Gutiyama, Luciana Mayumi
Solza, Cristiana
Zalcberg, Ilana Renault
author_sort Baptista, Renata Lyrio Rafael
collection PubMed
description Although most cases of myeloid neoplasms are sporadic, a small subset has been associated with germline mutations. The 2016 revision of the World Health Organization classification included these cases in a myeloid neoplasm group with a predisposing germline mutational background. These patients must have a different management and their families should get genetic counseling. Cases identification and outline of the major known syndromes characteristics will be discussed in this text.
format Online
Article
Text
id pubmed-5600909
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-56009092017-09-27 Familial Myelodysplastic/Acute Leukemia Syndromes—Myeloid Neoplasms with Germline Predisposition Baptista, Renata Lyrio Rafael dos Santos, Anna Cláudia Evangelista Gutiyama, Luciana Mayumi Solza, Cristiana Zalcberg, Ilana Renault Front Oncol Oncology Although most cases of myeloid neoplasms are sporadic, a small subset has been associated with germline mutations. The 2016 revision of the World Health Organization classification included these cases in a myeloid neoplasm group with a predisposing germline mutational background. These patients must have a different management and their families should get genetic counseling. Cases identification and outline of the major known syndromes characteristics will be discussed in this text. Frontiers Media S.A. 2017-09-12 /pmc/articles/PMC5600909/ /pubmed/28955657 http://dx.doi.org/10.3389/fonc.2017.00206 Text en Copyright © 2017 Baptista, dos Santos, Gutiyama, Solza and Zalcberg. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Baptista, Renata Lyrio Rafael
dos Santos, Anna Cláudia Evangelista
Gutiyama, Luciana Mayumi
Solza, Cristiana
Zalcberg, Ilana Renault
Familial Myelodysplastic/Acute Leukemia Syndromes—Myeloid Neoplasms with Germline Predisposition
title Familial Myelodysplastic/Acute Leukemia Syndromes—Myeloid Neoplasms with Germline Predisposition
title_full Familial Myelodysplastic/Acute Leukemia Syndromes—Myeloid Neoplasms with Germline Predisposition
title_fullStr Familial Myelodysplastic/Acute Leukemia Syndromes—Myeloid Neoplasms with Germline Predisposition
title_full_unstemmed Familial Myelodysplastic/Acute Leukemia Syndromes—Myeloid Neoplasms with Germline Predisposition
title_short Familial Myelodysplastic/Acute Leukemia Syndromes—Myeloid Neoplasms with Germline Predisposition
title_sort familial myelodysplastic/acute leukemia syndromes—myeloid neoplasms with germline predisposition
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600909/
https://www.ncbi.nlm.nih.gov/pubmed/28955657
http://dx.doi.org/10.3389/fonc.2017.00206
work_keys_str_mv AT baptistarenatalyriorafael familialmyelodysplasticacuteleukemiasyndromesmyeloidneoplasmswithgermlinepredisposition
AT dossantosannaclaudiaevangelista familialmyelodysplasticacuteleukemiasyndromesmyeloidneoplasmswithgermlinepredisposition
AT gutiyamalucianamayumi familialmyelodysplasticacuteleukemiasyndromesmyeloidneoplasmswithgermlinepredisposition
AT solzacristiana familialmyelodysplasticacuteleukemiasyndromesmyeloidneoplasmswithgermlinepredisposition
AT zalcbergilanarenault familialmyelodysplasticacuteleukemiasyndromesmyeloidneoplasmswithgermlinepredisposition

Ejemplares similares