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Conjecture Regarding Posttranslational Modifications to the Arabidopsis Type I Proton-Pumping Pyrophosphatase (AVP1)

Agbiotechnology uses genetic engineering to improve the output and value of crops. Altering the expression of the plant Type I Proton-pumping Pyrophosphatase (H(+)-PPase) has already proven to be a useful tool to enhance crop productivity. Despite the effective use of this gene in translational rese...

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Autores principales: Pizzio, Gaston A., Hirschi, Kendal D., Gaxiola, Roberto A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601048/
https://www.ncbi.nlm.nih.gov/pubmed/28955362
http://dx.doi.org/10.3389/fpls.2017.01572
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author Pizzio, Gaston A.
Hirschi, Kendal D.
Gaxiola, Roberto A.
author_facet Pizzio, Gaston A.
Hirschi, Kendal D.
Gaxiola, Roberto A.
author_sort Pizzio, Gaston A.
collection PubMed
description Agbiotechnology uses genetic engineering to improve the output and value of crops. Altering the expression of the plant Type I Proton-pumping Pyrophosphatase (H(+)-PPase) has already proven to be a useful tool to enhance crop productivity. Despite the effective use of this gene in translational research, information regarding the intracellular localization and functional plasticity of the pump remain largely enigmatic. Using computer modeling several putative phosphorylation, ubiquitination and sumoylation target sites were identified that may regulate Arabidopsis H(+)-PPase (AVP1- Arabidopsis Vacuolar Proton-pump 1) subcellular trafficking and activity. These putative regulatory sites will direct future research that specifically addresses the partitioning and transport characteristics of this pump. We posit that fine-tuning H(+)-PPases activity and cellular distribution will facilitate rationale strategies for further genetic improvements in crop productivity.
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spelling pubmed-56010482017-09-27 Conjecture Regarding Posttranslational Modifications to the Arabidopsis Type I Proton-Pumping Pyrophosphatase (AVP1) Pizzio, Gaston A. Hirschi, Kendal D. Gaxiola, Roberto A. Front Plant Sci Plant Science Agbiotechnology uses genetic engineering to improve the output and value of crops. Altering the expression of the plant Type I Proton-pumping Pyrophosphatase (H(+)-PPase) has already proven to be a useful tool to enhance crop productivity. Despite the effective use of this gene in translational research, information regarding the intracellular localization and functional plasticity of the pump remain largely enigmatic. Using computer modeling several putative phosphorylation, ubiquitination and sumoylation target sites were identified that may regulate Arabidopsis H(+)-PPase (AVP1- Arabidopsis Vacuolar Proton-pump 1) subcellular trafficking and activity. These putative regulatory sites will direct future research that specifically addresses the partitioning and transport characteristics of this pump. We posit that fine-tuning H(+)-PPases activity and cellular distribution will facilitate rationale strategies for further genetic improvements in crop productivity. Frontiers Media S.A. 2017-09-12 /pmc/articles/PMC5601048/ /pubmed/28955362 http://dx.doi.org/10.3389/fpls.2017.01572 Text en Copyright © 2017 Pizzio, Hirschi and Gaxiola. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Plant Science
Pizzio, Gaston A.
Hirschi, Kendal D.
Gaxiola, Roberto A.
Conjecture Regarding Posttranslational Modifications to the Arabidopsis Type I Proton-Pumping Pyrophosphatase (AVP1)
title Conjecture Regarding Posttranslational Modifications to the Arabidopsis Type I Proton-Pumping Pyrophosphatase (AVP1)
title_full Conjecture Regarding Posttranslational Modifications to the Arabidopsis Type I Proton-Pumping Pyrophosphatase (AVP1)
title_fullStr Conjecture Regarding Posttranslational Modifications to the Arabidopsis Type I Proton-Pumping Pyrophosphatase (AVP1)
title_full_unstemmed Conjecture Regarding Posttranslational Modifications to the Arabidopsis Type I Proton-Pumping Pyrophosphatase (AVP1)
title_short Conjecture Regarding Posttranslational Modifications to the Arabidopsis Type I Proton-Pumping Pyrophosphatase (AVP1)
title_sort conjecture regarding posttranslational modifications to the arabidopsis type i proton-pumping pyrophosphatase (avp1)
topic Plant Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601048/
https://www.ncbi.nlm.nih.gov/pubmed/28955362
http://dx.doi.org/10.3389/fpls.2017.01572
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