Genetic progression in gastrointestinal stromal tumors: mechanisms and molecular interventions

Gastrointestinal stromal tumors (GISTs) are the most common sarcomas in humans. Constitutively activating mutations in the KIT or PDGFRA receptor tyrosine kinases are the initiating oncogenic events. Most metastatic GISTs respond dramatically to therapies with KIT/PDGFRA inhibitors. Asymptomatic and...

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Detalles Bibliográficos
Autores principales: Li, Ke, Cheng, Haibo, Li, Zhang, Pang, Yuzhi, Jia, Xiaona, Xie, Feifei, Hu, Guohong, Cai, Qingping, Wang, Yuexiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601165/
https://www.ncbi.nlm.nih.gov/pubmed/28947997
http://dx.doi.org/10.18632/oncotarget.16014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601165/
https://www.ncbi.nlm.nih.gov/pubmed/28947997
http://dx.doi.org/10.18632/oncotarget.16014

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