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Dynamic Equilibrium of the Aurora A Kinase Activation Loop Revealed by Single‐Molecule Spectroscopy

The conformation of the activation loop (T‐loop) of protein kinases underlies enzymatic activity and influences the binding of small‐molecule inhibitors. By using single‐molecule fluorescence spectroscopy, we have determined that phosphorylated Aurora A kinase is in dynamic equilibrium between a DFG...

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Detalles Bibliográficos
Autores principales:	Gilburt, James A. H., Sarkar, Hajrah, Sheldrake, Peter, Blagg, Julian, Ying, Liming, Dodson, Charlotte A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601181/ https://www.ncbi.nlm.nih.gov/pubmed/28700101 http://dx.doi.org/10.1002/anie.201704654

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