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A Red‐Light‐Activated Ruthenium‐Caged NAMPT Inhibitor Remains Phototoxic in Hypoxic Cancer Cells

We describe two water‐soluble ruthenium complexes, [1]Cl(2) and [2]Cl(2), that photodissociate to release a cytotoxic nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with a low dose (21 J cm(−2)) of red light in an oxygen‐independent manner. Using a specific NAMPT activity assay, up to an 1...

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Detalles Bibliográficos
Autores principales:	Lameijer, Lucien N., Ernst, Daniël, Hopkins, Samantha L., Meijer, Michael S., Askes, Sven H. C., Le Dévédec, Sylvia E., Bonnet, Sylvestre
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601216/ https://www.ncbi.nlm.nih.gov/pubmed/28666065 http://dx.doi.org/10.1002/anie.201703890

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