Pro‐migratory and TGF‐β‐activating functions of αvβ6 integrin in pancreatic cancer are differentially regulated via an Eps8‐dependent GTPase switch

The integrin αvβ6 is up‐regulated in numerous carcinomas, where expression commonly correlates with poor prognosis. αvβ6 promotes tumour invasion, partly through regulation of proteases and cell migration, and is also the principal mechanism by which epithelial cells activate TGF‐β1; this latter fun...

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Detalles Bibliográficos
Autores principales: Tod, Jo, Hanley, Christopher J, Morgan, Mark R, Rucka, Marta, Mellows, Toby, Lopez, Maria‐Antoinette, Kiely, Philip, Moutasim, Karwan A, Frampton, Steven J, Sabnis, Durgagauri, Fine, David R, Johnson, Colin, Marshall, John F, Scita, Giorgio, Jenei, Veronika, Thomas, Gareth J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2017
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601247/
https://www.ncbi.nlm.nih.gov/pubmed/28608476
http://dx.doi.org/10.1002/path.4923

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601247/
https://www.ncbi.nlm.nih.gov/pubmed/28608476
http://dx.doi.org/10.1002/path.4923

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