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Oligodendroglial excitability mediated by glutamatergic inputs and Nav1.2 activation
Oligodendrocyte (OL) maturation and axon-glial communication are required for proper myelination in the developing brain. However, physiological properties of OLs remain largely uncharacterized in different brain regions. The roles of oligodendroglial voltage-activated Na(+) channels (Na(v)) and ele...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601459/ https://www.ncbi.nlm.nih.gov/pubmed/28916793 http://dx.doi.org/10.1038/s41467-017-00688-0 |
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author | Berret, Emmanuelle Barron, Tara Xu, Jie Debner, Emily Kim, Eun Jung Kim, Jun Hee |
author_facet | Berret, Emmanuelle Barron, Tara Xu, Jie Debner, Emily Kim, Eun Jung Kim, Jun Hee |
author_sort | Berret, Emmanuelle |
collection | PubMed |
description | Oligodendrocyte (OL) maturation and axon-glial communication are required for proper myelination in the developing brain. However, physiological properties of OLs remain largely uncharacterized in different brain regions. The roles of oligodendroglial voltage-activated Na(+) channels (Na(v)) and electrical excitability in relation to maturation to the myelinating stage are controversial, although oligodendroglial excitability is potentially important for promoting axon myelination. Here we show spiking properties of OLs and their role in axon-glial communication in the auditory brainstem. A subpopulation of pre-myelinating OLs (pre-OLs) can generate Na(v)1.2-driven action potentials throughout postnatal development to early adulthood. In addition, excitable pre-OLs receive glutamatergic inputs from neighboring neurons that trigger pre-OL spikes. Knockdown of Na(v)1.2 channels in pre-OLs alters their morphology, reduces axon-OL interactions and impairs myelination. Our results suggest that Na(v)1.2-driven spiking of pre-OLs is an integral component of axon-glial communication and is required for the function and maturation of OLs to promote myelination. |
format | Online Article Text |
id | pubmed-5601459 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-56014592017-09-22 Oligodendroglial excitability mediated by glutamatergic inputs and Nav1.2 activation Berret, Emmanuelle Barron, Tara Xu, Jie Debner, Emily Kim, Eun Jung Kim, Jun Hee Nat Commun Article Oligodendrocyte (OL) maturation and axon-glial communication are required for proper myelination in the developing brain. However, physiological properties of OLs remain largely uncharacterized in different brain regions. The roles of oligodendroglial voltage-activated Na(+) channels (Na(v)) and electrical excitability in relation to maturation to the myelinating stage are controversial, although oligodendroglial excitability is potentially important for promoting axon myelination. Here we show spiking properties of OLs and their role in axon-glial communication in the auditory brainstem. A subpopulation of pre-myelinating OLs (pre-OLs) can generate Na(v)1.2-driven action potentials throughout postnatal development to early adulthood. In addition, excitable pre-OLs receive glutamatergic inputs from neighboring neurons that trigger pre-OL spikes. Knockdown of Na(v)1.2 channels in pre-OLs alters their morphology, reduces axon-OL interactions and impairs myelination. Our results suggest that Na(v)1.2-driven spiking of pre-OLs is an integral component of axon-glial communication and is required for the function and maturation of OLs to promote myelination. Nature Publishing Group UK 2017-09-15 /pmc/articles/PMC5601459/ /pubmed/28916793 http://dx.doi.org/10.1038/s41467-017-00688-0 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Berret, Emmanuelle Barron, Tara Xu, Jie Debner, Emily Kim, Eun Jung Kim, Jun Hee Oligodendroglial excitability mediated by glutamatergic inputs and Nav1.2 activation |
title | Oligodendroglial excitability mediated by glutamatergic inputs and Nav1.2 activation |
title_full | Oligodendroglial excitability mediated by glutamatergic inputs and Nav1.2 activation |
title_fullStr | Oligodendroglial excitability mediated by glutamatergic inputs and Nav1.2 activation |
title_full_unstemmed | Oligodendroglial excitability mediated by glutamatergic inputs and Nav1.2 activation |
title_short | Oligodendroglial excitability mediated by glutamatergic inputs and Nav1.2 activation |
title_sort | oligodendroglial excitability mediated by glutamatergic inputs and nav1.2 activation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601459/ https://www.ncbi.nlm.nih.gov/pubmed/28916793 http://dx.doi.org/10.1038/s41467-017-00688-0 |
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