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Chronic interfacing with the autonomic nervous system using carbon nanotube (CNT) yarn electrodes

The ability to reliably and safely communicate chronically with small diameter (100–300 µm) autonomic nerves could have a significant impact in fundamental biomedical research and clinical applications. However, this ability has remained elusive with existing neural interface technologies. Here we s...

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Autores principales: McCallum, Grant A., Sui, Xiaohong, Qiu, Chen, Marmerstein, Joseph, Zheng, Yang, Eggers, Thomas E., Hu, Chuangang, Dai, Liming, Durand, Dominique M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601469/
https://www.ncbi.nlm.nih.gov/pubmed/28916761
http://dx.doi.org/10.1038/s41598-017-10639-w
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author McCallum, Grant A.
Sui, Xiaohong
Qiu, Chen
Marmerstein, Joseph
Zheng, Yang
Eggers, Thomas E.
Hu, Chuangang
Dai, Liming
Durand, Dominique M.
author_facet McCallum, Grant A.
Sui, Xiaohong
Qiu, Chen
Marmerstein, Joseph
Zheng, Yang
Eggers, Thomas E.
Hu, Chuangang
Dai, Liming
Durand, Dominique M.
author_sort McCallum, Grant A.
collection PubMed
description The ability to reliably and safely communicate chronically with small diameter (100–300 µm) autonomic nerves could have a significant impact in fundamental biomedical research and clinical applications. However, this ability has remained elusive with existing neural interface technologies. Here we show a new chronic nerve interface using highly flexible materials with axon-like dimensions. The interface was implemented with carbon nanotube (CNT) yarn electrodes to chronically record neural activity from two separate autonomic nerves: the glossopharyngeal and vagus nerves. The recorded neural signals maintain a high signal-to-noise ratio (>10 dB) in chronic implant models. We further demonstrate the ability to process the neural activity to detect hypoxic and gastric extension events from the glossopharyngeal and vagus nerves, respectively. These results establish a novel, chronic platform neural interfacing technique with the autonomic nervous system and demonstrate the possibility of regulating internal organ function, leading to new bioelectronic therapies and patient health monitoring.
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spelling pubmed-56014692017-09-20 Chronic interfacing with the autonomic nervous system using carbon nanotube (CNT) yarn electrodes McCallum, Grant A. Sui, Xiaohong Qiu, Chen Marmerstein, Joseph Zheng, Yang Eggers, Thomas E. Hu, Chuangang Dai, Liming Durand, Dominique M. Sci Rep Article The ability to reliably and safely communicate chronically with small diameter (100–300 µm) autonomic nerves could have a significant impact in fundamental biomedical research and clinical applications. However, this ability has remained elusive with existing neural interface technologies. Here we show a new chronic nerve interface using highly flexible materials with axon-like dimensions. The interface was implemented with carbon nanotube (CNT) yarn electrodes to chronically record neural activity from two separate autonomic nerves: the glossopharyngeal and vagus nerves. The recorded neural signals maintain a high signal-to-noise ratio (>10 dB) in chronic implant models. We further demonstrate the ability to process the neural activity to detect hypoxic and gastric extension events from the glossopharyngeal and vagus nerves, respectively. These results establish a novel, chronic platform neural interfacing technique with the autonomic nervous system and demonstrate the possibility of regulating internal organ function, leading to new bioelectronic therapies and patient health monitoring. Nature Publishing Group UK 2017-09-15 /pmc/articles/PMC5601469/ /pubmed/28916761 http://dx.doi.org/10.1038/s41598-017-10639-w Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
McCallum, Grant A.
Sui, Xiaohong
Qiu, Chen
Marmerstein, Joseph
Zheng, Yang
Eggers, Thomas E.
Hu, Chuangang
Dai, Liming
Durand, Dominique M.
Chronic interfacing with the autonomic nervous system using carbon nanotube (CNT) yarn electrodes
title Chronic interfacing with the autonomic nervous system using carbon nanotube (CNT) yarn electrodes
title_full Chronic interfacing with the autonomic nervous system using carbon nanotube (CNT) yarn electrodes
title_fullStr Chronic interfacing with the autonomic nervous system using carbon nanotube (CNT) yarn electrodes
title_full_unstemmed Chronic interfacing with the autonomic nervous system using carbon nanotube (CNT) yarn electrodes
title_short Chronic interfacing with the autonomic nervous system using carbon nanotube (CNT) yarn electrodes
title_sort chronic interfacing with the autonomic nervous system using carbon nanotube (cnt) yarn electrodes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601469/
https://www.ncbi.nlm.nih.gov/pubmed/28916761
http://dx.doi.org/10.1038/s41598-017-10639-w
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