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Opportunities for research in molecular radiotherapy

Cancer has been treated with radiopharmaceuticals for 80 years. A recent National Cancer Research Institute report from the Clinical and Translational Radiotherapy Research Working Group reviews the current status of molecular radiotherapy and has highlighted the barriers to and opportunities for in...

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Autores principales: Flux, Glenn D, O'Sullivan, Joe, Gaze, Mark N, Prise, Kevin M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The British Institute of Radiology. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601516/
https://www.ncbi.nlm.nih.gov/pubmed/28055251
http://dx.doi.org/10.1259/bjr.20160921
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author Flux, Glenn D
O'Sullivan, Joe
Gaze, Mark N
Prise, Kevin M
author_facet Flux, Glenn D
O'Sullivan, Joe
Gaze, Mark N
Prise, Kevin M
author_sort Flux, Glenn D
collection PubMed
description Cancer has been treated with radiopharmaceuticals for 80 years. A recent National Cancer Research Institute report from the Clinical and Translational Radiotherapy Research Working Group reviews the current status of molecular radiotherapy and has highlighted the barriers to and opportunities for increased research activities. The report recommends a number of actions to promote this field, which in the dawning age of personalized medicine and theragnostics is of increasing importance, particularly with the clinical introduction of a range of new commercial radiotherapeutics at costs in line with those seen for conventional chemotherapeutics. These recommendations recognize the importance of a multidisciplinary approach to the development of molecular radiotherapy and the particular need for investment in radiopharmacies and personalized dosimetry. There are many areas to be investigated including adaptive treatment planning, the use of radiosensitizers and translational radiation biology. Progress in these areas will result in significant patient benefit and more cost-effective use of increasingly expensive therapeutic radiopharmaceuticals. A concerted effort from the community, from funding bodies and from health service providers is now needed to address the scientific and logistical changes necessary to realize the potential offered by this currently underused treatment modality.
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spelling pubmed-56015162017-09-22 Opportunities for research in molecular radiotherapy Flux, Glenn D O'Sullivan, Joe Gaze, Mark N Prise, Kevin M Br J Radiol Commentary Cancer has been treated with radiopharmaceuticals for 80 years. A recent National Cancer Research Institute report from the Clinical and Translational Radiotherapy Research Working Group reviews the current status of molecular radiotherapy and has highlighted the barriers to and opportunities for increased research activities. The report recommends a number of actions to promote this field, which in the dawning age of personalized medicine and theragnostics is of increasing importance, particularly with the clinical introduction of a range of new commercial radiotherapeutics at costs in line with those seen for conventional chemotherapeutics. These recommendations recognize the importance of a multidisciplinary approach to the development of molecular radiotherapy and the particular need for investment in radiopharmacies and personalized dosimetry. There are many areas to be investigated including adaptive treatment planning, the use of radiosensitizers and translational radiation biology. Progress in these areas will result in significant patient benefit and more cost-effective use of increasingly expensive therapeutic radiopharmaceuticals. A concerted effort from the community, from funding bodies and from health service providers is now needed to address the scientific and logistical changes necessary to realize the potential offered by this currently underused treatment modality. The British Institute of Radiology. 2017-03 2017-02-25 /pmc/articles/PMC5601516/ /pubmed/28055251 http://dx.doi.org/10.1259/bjr.20160921 Text en © 2017 The Authors. Published by the British Institute of Radiology This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 Unported License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
spellingShingle Commentary
Flux, Glenn D
O'Sullivan, Joe
Gaze, Mark N
Prise, Kevin M
Opportunities for research in molecular radiotherapy
title Opportunities for research in molecular radiotherapy
title_full Opportunities for research in molecular radiotherapy
title_fullStr Opportunities for research in molecular radiotherapy
title_full_unstemmed Opportunities for research in molecular radiotherapy
title_short Opportunities for research in molecular radiotherapy
title_sort opportunities for research in molecular radiotherapy
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601516/
https://www.ncbi.nlm.nih.gov/pubmed/28055251
http://dx.doi.org/10.1259/bjr.20160921
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