A novel immunotherapy targeting MMP-14 limits hypoxia, immune suppression and metastasis in triple-negative breast cancer models

Matrix metalloproteinase-14 (MMP-14) is a clinically relevant target in metastatic cancers due to its role in tumor progression and metastasis. Since active MMP-14 is localized on the cell surface, it is amenable to antibody-mediated blockade in cancer, and here we describe our efforts to develop no...

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Detalles Bibliográficos
Autores principales: Ling, Binbing, Watt, Kathleen, Banerjee, Sunandan, Newsted, Daniel, Truesdell, Peter, Adams, Jarrett, Sidhu, Sachdev S., Craig, Andrew W.B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601659/
https://www.ncbi.nlm.nih.gov/pubmed/28938563
http://dx.doi.org/10.18632/oncotarget.17702

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