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The effects of air pollution on mortality and clinicopathological features of esophageal cancer

This study aimed to estimate the associations between air pollution and esophageal cancer. In the ecologic cross-sectional study, correlation analyses were made between city-level mean concentrations of particulate matter less than 10μm in aerodynamic diameter (PM(10)), SO(2), NO(2) and city-level a...

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Autores principales: Huang, Xiaochen, Guan, Shanghui, Wang, Jiangfeng, Zhao, Linli, Jia, Yibin, Lu, Zilong, Yin, Cuiping, Yang, Shengsi, Song, Qingxu, Han, Lihui, Wang, Cong, Li, Jingyi, Zhou, Wei, Guo, Xiaolei, Cheng, Yufeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601675/
https://www.ncbi.nlm.nih.gov/pubmed/28938579
http://dx.doi.org/10.18632/oncotarget.17266
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author Huang, Xiaochen
Guan, Shanghui
Wang, Jiangfeng
Zhao, Linli
Jia, Yibin
Lu, Zilong
Yin, Cuiping
Yang, Shengsi
Song, Qingxu
Han, Lihui
Wang, Cong
Li, Jingyi
Zhou, Wei
Guo, Xiaolei
Cheng, Yufeng
author_facet Huang, Xiaochen
Guan, Shanghui
Wang, Jiangfeng
Zhao, Linli
Jia, Yibin
Lu, Zilong
Yin, Cuiping
Yang, Shengsi
Song, Qingxu
Han, Lihui
Wang, Cong
Li, Jingyi
Zhou, Wei
Guo, Xiaolei
Cheng, Yufeng
author_sort Huang, Xiaochen
collection PubMed
description This study aimed to estimate the associations between air pollution and esophageal cancer. In the ecologic cross-sectional study, correlation analyses were made between city-level mean concentrations of particulate matter less than 10μm in aerodynamic diameter (PM(10)), SO(2), NO(2) and city-level age-standardized mortality rates of esophageal cancer in Shandong Province, China. PM(10) (p=0.046) and NO(2) (p=0.03) both had significant linear correlations with esophageal cancer mortality rates. After introducing smoking as a risk factor in models of multiple linear regression analyses, PM(10) was still an independent risk factor that increased esophageal cancer mortality rates. This study further compared clinicopathological features of 1,255 eligible esophageal squamous cell carcinoma patients by dividing them into different pollution level groups. There was statistically significant difference in gender distributions (p=0.02) between groups after subgroup analysis. Female patients accounted for a higher proportion in the high PM(10) level group than in the low PM(10) level group. It suggested that females were more sensitive to higher PM(10) level pollution. The features that manifested the degree of malignancy of esophageal cancer, including primary tumor invasion, regional lymph nodes metastasis, histological grade, stage, lymph-vascular invasion and tumor size demonstrated no statistically significant difference between groups.
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spelling pubmed-56016752017-09-21 The effects of air pollution on mortality and clinicopathological features of esophageal cancer Huang, Xiaochen Guan, Shanghui Wang, Jiangfeng Zhao, Linli Jia, Yibin Lu, Zilong Yin, Cuiping Yang, Shengsi Song, Qingxu Han, Lihui Wang, Cong Li, Jingyi Zhou, Wei Guo, Xiaolei Cheng, Yufeng Oncotarget Research Paper This study aimed to estimate the associations between air pollution and esophageal cancer. In the ecologic cross-sectional study, correlation analyses were made between city-level mean concentrations of particulate matter less than 10μm in aerodynamic diameter (PM(10)), SO(2), NO(2) and city-level age-standardized mortality rates of esophageal cancer in Shandong Province, China. PM(10) (p=0.046) and NO(2) (p=0.03) both had significant linear correlations with esophageal cancer mortality rates. After introducing smoking as a risk factor in models of multiple linear regression analyses, PM(10) was still an independent risk factor that increased esophageal cancer mortality rates. This study further compared clinicopathological features of 1,255 eligible esophageal squamous cell carcinoma patients by dividing them into different pollution level groups. There was statistically significant difference in gender distributions (p=0.02) between groups after subgroup analysis. Female patients accounted for a higher proportion in the high PM(10) level group than in the low PM(10) level group. It suggested that females were more sensitive to higher PM(10) level pollution. The features that manifested the degree of malignancy of esophageal cancer, including primary tumor invasion, regional lymph nodes metastasis, histological grade, stage, lymph-vascular invasion and tumor size demonstrated no statistically significant difference between groups. Impact Journals LLC 2017-04-20 /pmc/articles/PMC5601675/ /pubmed/28938579 http://dx.doi.org/10.18632/oncotarget.17266 Text en Copyright: © 2017 Huang et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Huang, Xiaochen
Guan, Shanghui
Wang, Jiangfeng
Zhao, Linli
Jia, Yibin
Lu, Zilong
Yin, Cuiping
Yang, Shengsi
Song, Qingxu
Han, Lihui
Wang, Cong
Li, Jingyi
Zhou, Wei
Guo, Xiaolei
Cheng, Yufeng
The effects of air pollution on mortality and clinicopathological features of esophageal cancer
title The effects of air pollution on mortality and clinicopathological features of esophageal cancer
title_full The effects of air pollution on mortality and clinicopathological features of esophageal cancer
title_fullStr The effects of air pollution on mortality and clinicopathological features of esophageal cancer
title_full_unstemmed The effects of air pollution on mortality and clinicopathological features of esophageal cancer
title_short The effects of air pollution on mortality and clinicopathological features of esophageal cancer
title_sort effects of air pollution on mortality and clinicopathological features of esophageal cancer
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601675/
https://www.ncbi.nlm.nih.gov/pubmed/28938579
http://dx.doi.org/10.18632/oncotarget.17266
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