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The effects of air pollution on mortality and clinicopathological features of esophageal cancer
This study aimed to estimate the associations between air pollution and esophageal cancer. In the ecologic cross-sectional study, correlation analyses were made between city-level mean concentrations of particulate matter less than 10μm in aerodynamic diameter (PM(10)), SO(2), NO(2) and city-level a...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601675/ https://www.ncbi.nlm.nih.gov/pubmed/28938579 http://dx.doi.org/10.18632/oncotarget.17266 |
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author | Huang, Xiaochen Guan, Shanghui Wang, Jiangfeng Zhao, Linli Jia, Yibin Lu, Zilong Yin, Cuiping Yang, Shengsi Song, Qingxu Han, Lihui Wang, Cong Li, Jingyi Zhou, Wei Guo, Xiaolei Cheng, Yufeng |
author_facet | Huang, Xiaochen Guan, Shanghui Wang, Jiangfeng Zhao, Linli Jia, Yibin Lu, Zilong Yin, Cuiping Yang, Shengsi Song, Qingxu Han, Lihui Wang, Cong Li, Jingyi Zhou, Wei Guo, Xiaolei Cheng, Yufeng |
author_sort | Huang, Xiaochen |
collection | PubMed |
description | This study aimed to estimate the associations between air pollution and esophageal cancer. In the ecologic cross-sectional study, correlation analyses were made between city-level mean concentrations of particulate matter less than 10μm in aerodynamic diameter (PM(10)), SO(2), NO(2) and city-level age-standardized mortality rates of esophageal cancer in Shandong Province, China. PM(10) (p=0.046) and NO(2) (p=0.03) both had significant linear correlations with esophageal cancer mortality rates. After introducing smoking as a risk factor in models of multiple linear regression analyses, PM(10) was still an independent risk factor that increased esophageal cancer mortality rates. This study further compared clinicopathological features of 1,255 eligible esophageal squamous cell carcinoma patients by dividing them into different pollution level groups. There was statistically significant difference in gender distributions (p=0.02) between groups after subgroup analysis. Female patients accounted for a higher proportion in the high PM(10) level group than in the low PM(10) level group. It suggested that females were more sensitive to higher PM(10) level pollution. The features that manifested the degree of malignancy of esophageal cancer, including primary tumor invasion, regional lymph nodes metastasis, histological grade, stage, lymph-vascular invasion and tumor size demonstrated no statistically significant difference between groups. |
format | Online Article Text |
id | pubmed-5601675 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-56016752017-09-21 The effects of air pollution on mortality and clinicopathological features of esophageal cancer Huang, Xiaochen Guan, Shanghui Wang, Jiangfeng Zhao, Linli Jia, Yibin Lu, Zilong Yin, Cuiping Yang, Shengsi Song, Qingxu Han, Lihui Wang, Cong Li, Jingyi Zhou, Wei Guo, Xiaolei Cheng, Yufeng Oncotarget Research Paper This study aimed to estimate the associations between air pollution and esophageal cancer. In the ecologic cross-sectional study, correlation analyses were made between city-level mean concentrations of particulate matter less than 10μm in aerodynamic diameter (PM(10)), SO(2), NO(2) and city-level age-standardized mortality rates of esophageal cancer in Shandong Province, China. PM(10) (p=0.046) and NO(2) (p=0.03) both had significant linear correlations with esophageal cancer mortality rates. After introducing smoking as a risk factor in models of multiple linear regression analyses, PM(10) was still an independent risk factor that increased esophageal cancer mortality rates. This study further compared clinicopathological features of 1,255 eligible esophageal squamous cell carcinoma patients by dividing them into different pollution level groups. There was statistically significant difference in gender distributions (p=0.02) between groups after subgroup analysis. Female patients accounted for a higher proportion in the high PM(10) level group than in the low PM(10) level group. It suggested that females were more sensitive to higher PM(10) level pollution. The features that manifested the degree of malignancy of esophageal cancer, including primary tumor invasion, regional lymph nodes metastasis, histological grade, stage, lymph-vascular invasion and tumor size demonstrated no statistically significant difference between groups. Impact Journals LLC 2017-04-20 /pmc/articles/PMC5601675/ /pubmed/28938579 http://dx.doi.org/10.18632/oncotarget.17266 Text en Copyright: © 2017 Huang et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Huang, Xiaochen Guan, Shanghui Wang, Jiangfeng Zhao, Linli Jia, Yibin Lu, Zilong Yin, Cuiping Yang, Shengsi Song, Qingxu Han, Lihui Wang, Cong Li, Jingyi Zhou, Wei Guo, Xiaolei Cheng, Yufeng The effects of air pollution on mortality and clinicopathological features of esophageal cancer |
title | The effects of air pollution on mortality and clinicopathological features of esophageal cancer |
title_full | The effects of air pollution on mortality and clinicopathological features of esophageal cancer |
title_fullStr | The effects of air pollution on mortality and clinicopathological features of esophageal cancer |
title_full_unstemmed | The effects of air pollution on mortality and clinicopathological features of esophageal cancer |
title_short | The effects of air pollution on mortality and clinicopathological features of esophageal cancer |
title_sort | effects of air pollution on mortality and clinicopathological features of esophageal cancer |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601675/ https://www.ncbi.nlm.nih.gov/pubmed/28938579 http://dx.doi.org/10.18632/oncotarget.17266 |
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