The long noncoding RNA HOTAIR activates the Hippo pathway by directly binding to SAV1 in renal cell carcinoma

The long noncoding RNA HOTAIR promotes the development and progression of several tumors. Here, the clinical significance and role of HOTAIR in renal cell carcinoma (RCC) tumorigenesis were explored. The results showed that increased expression of HOTAIR predicted a poor prognosis of RCC after surge...

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Autores principales: Hu, Guanghui, Dong, Binbin, Zhang, Jingwei, Zhai, Wei, Xie, Tiancheng, Huang, Bisheng, Huang, Chi, Yao, Xudong, Zheng, Junhua, Che, Jianping, Xu, Yun-Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601682/
https://www.ncbi.nlm.nih.gov/pubmed/28938586
http://dx.doi.org/10.18632/oncotarget.17414
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author Hu, Guanghui
Dong, Binbin
Zhang, Jingwei
Zhai, Wei
Xie, Tiancheng
Huang, Bisheng
Huang, Chi
Yao, Xudong
Zheng, Junhua
Che, Jianping
Xu, Yun-Fei
author_facet Hu, Guanghui
Dong, Binbin
Zhang, Jingwei
Zhai, Wei
Xie, Tiancheng
Huang, Bisheng
Huang, Chi
Yao, Xudong
Zheng, Junhua
Che, Jianping
Xu, Yun-Fei
author_sort Hu, Guanghui
collection PubMed
description The long noncoding RNA HOTAIR promotes the development and progression of several tumors. Here, the clinical significance and role of HOTAIR in renal cell carcinoma (RCC) tumorigenesis were explored. The results showed that increased expression of HOTAIR predicted a poor prognosis of RCC after surgery. HOTAIR promoted RCC cell proliferation and growth in vitro and in vivo. The expressions of HOTAIR and Salvador homolog 1 (SAV1) were inversely correlated in clinical RCC samples. HOTAIR downregulated SAV1 by directly binding to the SAV1 protein and enhanced histone H3K27 methylation. Loss of function of SAV1 activated the Hippo pathway. HOTAIR could be a potential therapeutic target in RCC.
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spelling pubmed-56016822017-09-21 The long noncoding RNA HOTAIR activates the Hippo pathway by directly binding to SAV1 in renal cell carcinoma Hu, Guanghui Dong, Binbin Zhang, Jingwei Zhai, Wei Xie, Tiancheng Huang, Bisheng Huang, Chi Yao, Xudong Zheng, Junhua Che, Jianping Xu, Yun-Fei Oncotarget Research Paper The long noncoding RNA HOTAIR promotes the development and progression of several tumors. Here, the clinical significance and role of HOTAIR in renal cell carcinoma (RCC) tumorigenesis were explored. The results showed that increased expression of HOTAIR predicted a poor prognosis of RCC after surgery. HOTAIR promoted RCC cell proliferation and growth in vitro and in vivo. The expressions of HOTAIR and Salvador homolog 1 (SAV1) were inversely correlated in clinical RCC samples. HOTAIR downregulated SAV1 by directly binding to the SAV1 protein and enhanced histone H3K27 methylation. Loss of function of SAV1 activated the Hippo pathway. HOTAIR could be a potential therapeutic target in RCC. Impact Journals LLC 2017-04-25 /pmc/articles/PMC5601682/ /pubmed/28938586 http://dx.doi.org/10.18632/oncotarget.17414 Text en Copyright: © 2017 Hu et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Hu, Guanghui
Dong, Binbin
Zhang, Jingwei
Zhai, Wei
Xie, Tiancheng
Huang, Bisheng
Huang, Chi
Yao, Xudong
Zheng, Junhua
Che, Jianping
Xu, Yun-Fei
The long noncoding RNA HOTAIR activates the Hippo pathway by directly binding to SAV1 in renal cell carcinoma
title The long noncoding RNA HOTAIR activates the Hippo pathway by directly binding to SAV1 in renal cell carcinoma
title_full The long noncoding RNA HOTAIR activates the Hippo pathway by directly binding to SAV1 in renal cell carcinoma
title_fullStr The long noncoding RNA HOTAIR activates the Hippo pathway by directly binding to SAV1 in renal cell carcinoma
title_full_unstemmed The long noncoding RNA HOTAIR activates the Hippo pathway by directly binding to SAV1 in renal cell carcinoma
title_short The long noncoding RNA HOTAIR activates the Hippo pathway by directly binding to SAV1 in renal cell carcinoma
title_sort long noncoding rna hotair activates the hippo pathway by directly binding to sav1 in renal cell carcinoma
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601682/
https://www.ncbi.nlm.nih.gov/pubmed/28938586
http://dx.doi.org/10.18632/oncotarget.17414
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