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Visible-light-sensitive titanium dioxide nanoplatform for tumor-responsive Fe2+ liberating and artemisinin delivery

Artemisinin is a kind of Fe(2+)-dependent drugs. Artemisinin and Fe(2+) co-transport systems can improve its anti-tumor effect. In this study, a visible light-sensitive nanoplatform (HA-TiO(2)-IONPs/ART) was developed. Detailed investigation demonstrated that HA-TiO(2)-IONPs/ART could realize Fe(2+)...

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Detalles Bibliográficos
Autores principales: Zhang, Huijuan, Zhang, Hongling, Zhu, Xing, Zhang, Xiaoge, Chen, Qianqian, Chen, Jianjiao, Hou, Lin, Zhang, Zhenzhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601688/
https://www.ncbi.nlm.nih.gov/pubmed/28938592
http://dx.doi.org/10.18632/oncotarget.17639
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author Zhang, Huijuan
Zhang, Hongling
Zhu, Xing
Zhang, Xiaoge
Chen, Qianqian
Chen, Jianjiao
Hou, Lin
Zhang, Zhenzhong
author_facet Zhang, Huijuan
Zhang, Hongling
Zhu, Xing
Zhang, Xiaoge
Chen, Qianqian
Chen, Jianjiao
Hou, Lin
Zhang, Zhenzhong
author_sort Zhang, Huijuan
collection PubMed
description Artemisinin is a kind of Fe(2+)-dependent drugs. Artemisinin and Fe(2+) co-transport systems can improve its anti-tumor effect. In this study, a visible light-sensitive nanoplatform (HA-TiO(2)-IONPs/ART) was developed. Detailed investigation demonstrated that HA-TiO(2)-IONPs/ART could realize Fe(2+) and artemisinin synchronous co-delivery and tumor-responsive release. This feature enhanced the anti-tumor efficiency of artemisinin significantly. In vitro results proved that hyaluronic acid modification could improve the biocompatibility, dispersion stability and cytophagy ability of nanocarriers. Furthermore, this drug delivery system could generate reactive oxygen species under visual light irradiation. In vitro and in vivo experiments demonstrated that HA-TiO(2)-IONPs/ART combining with laser irradiation displayed the best anti-tumor efficacy. This study affords a promising idea to improve the curative efficiency of artemisinin analogs for cancer therapy.
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spelling pubmed-56016882017-09-21 Visible-light-sensitive titanium dioxide nanoplatform for tumor-responsive Fe2+ liberating and artemisinin delivery Zhang, Huijuan Zhang, Hongling Zhu, Xing Zhang, Xiaoge Chen, Qianqian Chen, Jianjiao Hou, Lin Zhang, Zhenzhong Oncotarget Research Paper Artemisinin is a kind of Fe(2+)-dependent drugs. Artemisinin and Fe(2+) co-transport systems can improve its anti-tumor effect. In this study, a visible light-sensitive nanoplatform (HA-TiO(2)-IONPs/ART) was developed. Detailed investigation demonstrated that HA-TiO(2)-IONPs/ART could realize Fe(2+) and artemisinin synchronous co-delivery and tumor-responsive release. This feature enhanced the anti-tumor efficiency of artemisinin significantly. In vitro results proved that hyaluronic acid modification could improve the biocompatibility, dispersion stability and cytophagy ability of nanocarriers. Furthermore, this drug delivery system could generate reactive oxygen species under visual light irradiation. In vitro and in vivo experiments demonstrated that HA-TiO(2)-IONPs/ART combining with laser irradiation displayed the best anti-tumor efficacy. This study affords a promising idea to improve the curative efficiency of artemisinin analogs for cancer therapy. Impact Journals LLC 2017-05-05 /pmc/articles/PMC5601688/ /pubmed/28938592 http://dx.doi.org/10.18632/oncotarget.17639 Text en Copyright: © 2017 Zhang et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Zhang, Huijuan
Zhang, Hongling
Zhu, Xing
Zhang, Xiaoge
Chen, Qianqian
Chen, Jianjiao
Hou, Lin
Zhang, Zhenzhong
Visible-light-sensitive titanium dioxide nanoplatform for tumor-responsive Fe2+ liberating and artemisinin delivery
title Visible-light-sensitive titanium dioxide nanoplatform for tumor-responsive Fe2+ liberating and artemisinin delivery
title_full Visible-light-sensitive titanium dioxide nanoplatform for tumor-responsive Fe2+ liberating and artemisinin delivery
title_fullStr Visible-light-sensitive titanium dioxide nanoplatform for tumor-responsive Fe2+ liberating and artemisinin delivery
title_full_unstemmed Visible-light-sensitive titanium dioxide nanoplatform for tumor-responsive Fe2+ liberating and artemisinin delivery
title_short Visible-light-sensitive titanium dioxide nanoplatform for tumor-responsive Fe2+ liberating and artemisinin delivery
title_sort visible-light-sensitive titanium dioxide nanoplatform for tumor-responsive fe2+ liberating and artemisinin delivery
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601688/
https://www.ncbi.nlm.nih.gov/pubmed/28938592
http://dx.doi.org/10.18632/oncotarget.17639
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