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Visible-light-sensitive titanium dioxide nanoplatform for tumor-responsive Fe2+ liberating and artemisinin delivery
Artemisinin is a kind of Fe(2+)-dependent drugs. Artemisinin and Fe(2+) co-transport systems can improve its anti-tumor effect. In this study, a visible light-sensitive nanoplatform (HA-TiO(2)-IONPs/ART) was developed. Detailed investigation demonstrated that HA-TiO(2)-IONPs/ART could realize Fe(2+)...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601688/ https://www.ncbi.nlm.nih.gov/pubmed/28938592 http://dx.doi.org/10.18632/oncotarget.17639 |
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author | Zhang, Huijuan Zhang, Hongling Zhu, Xing Zhang, Xiaoge Chen, Qianqian Chen, Jianjiao Hou, Lin Zhang, Zhenzhong |
author_facet | Zhang, Huijuan Zhang, Hongling Zhu, Xing Zhang, Xiaoge Chen, Qianqian Chen, Jianjiao Hou, Lin Zhang, Zhenzhong |
author_sort | Zhang, Huijuan |
collection | PubMed |
description | Artemisinin is a kind of Fe(2+)-dependent drugs. Artemisinin and Fe(2+) co-transport systems can improve its anti-tumor effect. In this study, a visible light-sensitive nanoplatform (HA-TiO(2)-IONPs/ART) was developed. Detailed investigation demonstrated that HA-TiO(2)-IONPs/ART could realize Fe(2+) and artemisinin synchronous co-delivery and tumor-responsive release. This feature enhanced the anti-tumor efficiency of artemisinin significantly. In vitro results proved that hyaluronic acid modification could improve the biocompatibility, dispersion stability and cytophagy ability of nanocarriers. Furthermore, this drug delivery system could generate reactive oxygen species under visual light irradiation. In vitro and in vivo experiments demonstrated that HA-TiO(2)-IONPs/ART combining with laser irradiation displayed the best anti-tumor efficacy. This study affords a promising idea to improve the curative efficiency of artemisinin analogs for cancer therapy. |
format | Online Article Text |
id | pubmed-5601688 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-56016882017-09-21 Visible-light-sensitive titanium dioxide nanoplatform for tumor-responsive Fe2+ liberating and artemisinin delivery Zhang, Huijuan Zhang, Hongling Zhu, Xing Zhang, Xiaoge Chen, Qianqian Chen, Jianjiao Hou, Lin Zhang, Zhenzhong Oncotarget Research Paper Artemisinin is a kind of Fe(2+)-dependent drugs. Artemisinin and Fe(2+) co-transport systems can improve its anti-tumor effect. In this study, a visible light-sensitive nanoplatform (HA-TiO(2)-IONPs/ART) was developed. Detailed investigation demonstrated that HA-TiO(2)-IONPs/ART could realize Fe(2+) and artemisinin synchronous co-delivery and tumor-responsive release. This feature enhanced the anti-tumor efficiency of artemisinin significantly. In vitro results proved that hyaluronic acid modification could improve the biocompatibility, dispersion stability and cytophagy ability of nanocarriers. Furthermore, this drug delivery system could generate reactive oxygen species under visual light irradiation. In vitro and in vivo experiments demonstrated that HA-TiO(2)-IONPs/ART combining with laser irradiation displayed the best anti-tumor efficacy. This study affords a promising idea to improve the curative efficiency of artemisinin analogs for cancer therapy. Impact Journals LLC 2017-05-05 /pmc/articles/PMC5601688/ /pubmed/28938592 http://dx.doi.org/10.18632/oncotarget.17639 Text en Copyright: © 2017 Zhang et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Zhang, Huijuan Zhang, Hongling Zhu, Xing Zhang, Xiaoge Chen, Qianqian Chen, Jianjiao Hou, Lin Zhang, Zhenzhong Visible-light-sensitive titanium dioxide nanoplatform for tumor-responsive Fe2+ liberating and artemisinin delivery |
title | Visible-light-sensitive titanium dioxide nanoplatform for tumor-responsive Fe2+ liberating and artemisinin delivery |
title_full | Visible-light-sensitive titanium dioxide nanoplatform for tumor-responsive Fe2+ liberating and artemisinin delivery |
title_fullStr | Visible-light-sensitive titanium dioxide nanoplatform for tumor-responsive Fe2+ liberating and artemisinin delivery |
title_full_unstemmed | Visible-light-sensitive titanium dioxide nanoplatform for tumor-responsive Fe2+ liberating and artemisinin delivery |
title_short | Visible-light-sensitive titanium dioxide nanoplatform for tumor-responsive Fe2+ liberating and artemisinin delivery |
title_sort | visible-light-sensitive titanium dioxide nanoplatform for tumor-responsive fe2+ liberating and artemisinin delivery |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601688/ https://www.ncbi.nlm.nih.gov/pubmed/28938592 http://dx.doi.org/10.18632/oncotarget.17639 |
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