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MicroRNA expression levels as diagnostic biomarkers for intraductal papillary mucinous neoplasm
Intraductal papillary mucinous neoplasms (IPMNs) are deadly exocrine mucinous tumors. Currently the molecular features and diagnostic markers of IPMNs are not well understood. In this study, we performed microRNA (miRNA) profiling assays to study the potential roles of miRNAs in IPMNs using 78 cases...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601690/ https://www.ncbi.nlm.nih.gov/pubmed/28938594 http://dx.doi.org/10.18632/oncotarget.17679 |
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author | Wang, Lei Zheng, Jianming Sun, Chang Wang, Li Jin, Gang Xin, Lei Jin, Zhendong Wang, Dong Li, Zhaoshen |
author_facet | Wang, Lei Zheng, Jianming Sun, Chang Wang, Li Jin, Gang Xin, Lei Jin, Zhendong Wang, Dong Li, Zhaoshen |
author_sort | Wang, Lei |
collection | PubMed |
description | Intraductal papillary mucinous neoplasms (IPMNs) are deadly exocrine mucinous tumors. Currently the molecular features and diagnostic markers of IPMNs are not well understood. In this study, we performed microRNA (miRNA) profiling assays to study the potential roles of miRNAs in IPMNs using 78 cases of IPMN patients and controls. When comparing the miRNA expression between IPMN patient samples and controls, we found that miR-210, miR-223, miR-221, miR-155 and miR-187 were differentially expressed in normal pancreas and IPMNs. We further studied the miRNA expression profiles in different pancreatic diseases and identified miRNA features that are associated with Chronic pancreatitis (CP), IPMN, and Pancreatic ductal adenocarcinoma (PDAC). Therefore, these miRNAs might serve as new risk biomarkers of IPMN and could be useful for future targeted therapies. |
format | Online Article Text |
id | pubmed-5601690 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-56016902017-09-21 MicroRNA expression levels as diagnostic biomarkers for intraductal papillary mucinous neoplasm Wang, Lei Zheng, Jianming Sun, Chang Wang, Li Jin, Gang Xin, Lei Jin, Zhendong Wang, Dong Li, Zhaoshen Oncotarget Research Paper Intraductal papillary mucinous neoplasms (IPMNs) are deadly exocrine mucinous tumors. Currently the molecular features and diagnostic markers of IPMNs are not well understood. In this study, we performed microRNA (miRNA) profiling assays to study the potential roles of miRNAs in IPMNs using 78 cases of IPMN patients and controls. When comparing the miRNA expression between IPMN patient samples and controls, we found that miR-210, miR-223, miR-221, miR-155 and miR-187 were differentially expressed in normal pancreas and IPMNs. We further studied the miRNA expression profiles in different pancreatic diseases and identified miRNA features that are associated with Chronic pancreatitis (CP), IPMN, and Pancreatic ductal adenocarcinoma (PDAC). Therefore, these miRNAs might serve as new risk biomarkers of IPMN and could be useful for future targeted therapies. Impact Journals LLC 2017-05-08 /pmc/articles/PMC5601690/ /pubmed/28938594 http://dx.doi.org/10.18632/oncotarget.17679 Text en Copyright: © 2017 Wang et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Wang, Lei Zheng, Jianming Sun, Chang Wang, Li Jin, Gang Xin, Lei Jin, Zhendong Wang, Dong Li, Zhaoshen MicroRNA expression levels as diagnostic biomarkers for intraductal papillary mucinous neoplasm |
title | MicroRNA expression levels as diagnostic biomarkers for intraductal papillary mucinous neoplasm |
title_full | MicroRNA expression levels as diagnostic biomarkers for intraductal papillary mucinous neoplasm |
title_fullStr | MicroRNA expression levels as diagnostic biomarkers for intraductal papillary mucinous neoplasm |
title_full_unstemmed | MicroRNA expression levels as diagnostic biomarkers for intraductal papillary mucinous neoplasm |
title_short | MicroRNA expression levels as diagnostic biomarkers for intraductal papillary mucinous neoplasm |
title_sort | microrna expression levels as diagnostic biomarkers for intraductal papillary mucinous neoplasm |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601690/ https://www.ncbi.nlm.nih.gov/pubmed/28938594 http://dx.doi.org/10.18632/oncotarget.17679 |
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