Cargando…

MicroRNA expression levels as diagnostic biomarkers for intraductal papillary mucinous neoplasm

Intraductal papillary mucinous neoplasms (IPMNs) are deadly exocrine mucinous tumors. Currently the molecular features and diagnostic markers of IPMNs are not well understood. In this study, we performed microRNA (miRNA) profiling assays to study the potential roles of miRNAs in IPMNs using 78 cases...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Lei, Zheng, Jianming, Sun, Chang, Wang, Li, Jin, Gang, Xin, Lei, Jin, Zhendong, Wang, Dong, Li, Zhaoshen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601690/
https://www.ncbi.nlm.nih.gov/pubmed/28938594
http://dx.doi.org/10.18632/oncotarget.17679
_version_ 1783264434109546496
author Wang, Lei
Zheng, Jianming
Sun, Chang
Wang, Li
Jin, Gang
Xin, Lei
Jin, Zhendong
Wang, Dong
Li, Zhaoshen
author_facet Wang, Lei
Zheng, Jianming
Sun, Chang
Wang, Li
Jin, Gang
Xin, Lei
Jin, Zhendong
Wang, Dong
Li, Zhaoshen
author_sort Wang, Lei
collection PubMed
description Intraductal papillary mucinous neoplasms (IPMNs) are deadly exocrine mucinous tumors. Currently the molecular features and diagnostic markers of IPMNs are not well understood. In this study, we performed microRNA (miRNA) profiling assays to study the potential roles of miRNAs in IPMNs using 78 cases of IPMN patients and controls. When comparing the miRNA expression between IPMN patient samples and controls, we found that miR-210, miR-223, miR-221, miR-155 and miR-187 were differentially expressed in normal pancreas and IPMNs. We further studied the miRNA expression profiles in different pancreatic diseases and identified miRNA features that are associated with Chronic pancreatitis (CP), IPMN, and Pancreatic ductal adenocarcinoma (PDAC). Therefore, these miRNAs might serve as new risk biomarkers of IPMN and could be useful for future targeted therapies.
format Online
Article
Text
id pubmed-5601690
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Impact Journals LLC
record_format MEDLINE/PubMed
spelling pubmed-56016902017-09-21 MicroRNA expression levels as diagnostic biomarkers for intraductal papillary mucinous neoplasm Wang, Lei Zheng, Jianming Sun, Chang Wang, Li Jin, Gang Xin, Lei Jin, Zhendong Wang, Dong Li, Zhaoshen Oncotarget Research Paper Intraductal papillary mucinous neoplasms (IPMNs) are deadly exocrine mucinous tumors. Currently the molecular features and diagnostic markers of IPMNs are not well understood. In this study, we performed microRNA (miRNA) profiling assays to study the potential roles of miRNAs in IPMNs using 78 cases of IPMN patients and controls. When comparing the miRNA expression between IPMN patient samples and controls, we found that miR-210, miR-223, miR-221, miR-155 and miR-187 were differentially expressed in normal pancreas and IPMNs. We further studied the miRNA expression profiles in different pancreatic diseases and identified miRNA features that are associated with Chronic pancreatitis (CP), IPMN, and Pancreatic ductal adenocarcinoma (PDAC). Therefore, these miRNAs might serve as new risk biomarkers of IPMN and could be useful for future targeted therapies. Impact Journals LLC 2017-05-08 /pmc/articles/PMC5601690/ /pubmed/28938594 http://dx.doi.org/10.18632/oncotarget.17679 Text en Copyright: © 2017 Wang et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Wang, Lei
Zheng, Jianming
Sun, Chang
Wang, Li
Jin, Gang
Xin, Lei
Jin, Zhendong
Wang, Dong
Li, Zhaoshen
MicroRNA expression levels as diagnostic biomarkers for intraductal papillary mucinous neoplasm
title MicroRNA expression levels as diagnostic biomarkers for intraductal papillary mucinous neoplasm
title_full MicroRNA expression levels as diagnostic biomarkers for intraductal papillary mucinous neoplasm
title_fullStr MicroRNA expression levels as diagnostic biomarkers for intraductal papillary mucinous neoplasm
title_full_unstemmed MicroRNA expression levels as diagnostic biomarkers for intraductal papillary mucinous neoplasm
title_short MicroRNA expression levels as diagnostic biomarkers for intraductal papillary mucinous neoplasm
title_sort microrna expression levels as diagnostic biomarkers for intraductal papillary mucinous neoplasm
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601690/
https://www.ncbi.nlm.nih.gov/pubmed/28938594
http://dx.doi.org/10.18632/oncotarget.17679
work_keys_str_mv AT wanglei micrornaexpressionlevelsasdiagnosticbiomarkersforintraductalpapillarymucinousneoplasm
AT zhengjianming micrornaexpressionlevelsasdiagnosticbiomarkersforintraductalpapillarymucinousneoplasm
AT sunchang micrornaexpressionlevelsasdiagnosticbiomarkersforintraductalpapillarymucinousneoplasm
AT wangli micrornaexpressionlevelsasdiagnosticbiomarkersforintraductalpapillarymucinousneoplasm
AT jingang micrornaexpressionlevelsasdiagnosticbiomarkersforintraductalpapillarymucinousneoplasm
AT xinlei micrornaexpressionlevelsasdiagnosticbiomarkersforintraductalpapillarymucinousneoplasm
AT jinzhendong micrornaexpressionlevelsasdiagnosticbiomarkersforintraductalpapillarymucinousneoplasm
AT wangdong micrornaexpressionlevelsasdiagnosticbiomarkersforintraductalpapillarymucinousneoplasm
AT lizhaoshen micrornaexpressionlevelsasdiagnosticbiomarkersforintraductalpapillarymucinousneoplasm