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High PHLPP1 expression levels predicts longer time of acquired resistance to EGFR tyrosine kinase inhibitors in patients with lung adenocarcinoma

BACKGROUND: In spite of an initial good response to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) in lung adenocarcinoma patients, resistance to treatment eventually occurs. Epidermal growth factor receptor (EGFR) activation stimulates Ras/Raf/Erk/MAPK and influences PI3K/A...

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Detalles Bibliográficos
Autores principales:	Xie, Youyou, Lv, Dongqing, Wang, Wei, Ye, Minhua, Chen, Xiaofeng, Yang, Haihua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601709/ https://www.ncbi.nlm.nih.gov/pubmed/28938613 http://dx.doi.org/10.18632/oncotarget.19777

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