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microRNA-455 targets cullin 3 to activate Nrf2 signaling and protect human osteoblasts from hydrogen peroxide

Over-production of hydrogen peroxide (H(2)O(2)) will lead to human osteoblast dysfunction and apoptosis, causing progression of osteoporosis and osteonecrosis. NF-E2-related factor 2 (Nrf2) is a well-characterized anti-oxidant signaling. Cullin 3 (Cul3) ubiquitin E3 ligase dictates Nrf2 degradation....

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Detalles Bibliográficos
Autores principales:	Xu, Dawei, Zhu, Hao, Wang, Chengniu, Zhu, Xinhui, Liu, Genxiang, Chen, Chu, Cui, Zhiming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601727/ https://www.ncbi.nlm.nih.gov/pubmed/28938631 http://dx.doi.org/10.18632/oncotarget.19486

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